Cyclosporine Immunosuppressant

Cyclosporine Immunosuppressant is available 2 times from Stressma labs

  • Origin
    Synthetic
  • Soluble in
    Soluble to 100 mM in DMSO, 50 mM in ethanol
  • Other name
    (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
  • PubMed number
    Refer to PubMed
  • Description
    Immunosuppressant
  • Warning information
    Non-hazardous
  • Representative figure legend
    Chemical structure of Cyclosporine (SIH-201), a Inhibits mitochondrial permeability pore opening. CAS #: 59865-13-3. Molecular Formula: C62H111N11O12 . Molecular Weight: 1202.63 g/mol. Chemical structure of Cyclosporine, a Inhibits mitochondrial permeability pore opening (SIH-201). CAS # 59865-13-3. Molecular Formula: C62H111N11O12 .
  • Stock availabilitIn Stock
    In Stock
  • Molecular weight
    1202,63 g/mol
  • Purity pourcentage
    >99%
  • Chemical formula
    C62H111N11O12
  • Tested applications
    To be tested
  • Primary research fields
    Cancer, Apoptosis
  • Total weight (kg)
    0.25
  • Release date
    8-Apr-2011
  • Scientific context
    Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
  • Product type
    Inhibitor
  • CAS number
    59865-13-3
  • Safety information
    Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R45 - May cause cancer R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302-H350-H360 Precautionary Phrases: P201-P308 + P313
  • Country of production
    Canada
  • Product category
    Small Molecules
  • Physical appearance
    White Solid
  • Tested reactivity
    To be tested
  • PubChem number
    5284373
  • Bibliography
    1. Heitman J., et al. (1992) New Biol. 4:448. 2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient

SIH-201-100MG | Cyclosporine, Immunosuppressantsize: 100 mg | 517.79 USD

  • Catalog number
    SIH-201-100MG
  • Supplier
  • Price
    517.79 USD
  • Size
    100 mg
  • Net weight (g)
    0.1
MeSH Data
  • Name
  • Concept
    Registry number:83HN0GTJ6D
    Scope note:A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
    CASN1 number:Cyclosporin A
  • Tree numbers
    • D04.345.566.235.300
    • D12.644.641.235.300
  • Qualifiers
    immunology, pharmacokinetics, therapeutic use, toxicity, poisoning, administration & dosage, adverse effects, agonists, blood, cerebrospinal fluid, chemical synthesis, contraindications, chemistry, urine, radiation effects, history, analysis, antagonists & inhibitors, classification, economics, isolation & purification, metabolism, pharmacology, standards, supply & distribution
Additional information

SIH-201-25MG | Cyclosporine, Immunosuppressantsize: 25 mg | 218.92 USD

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