Cyclin-dependent kinase inhibitor 2A_TAT, Human Recombinant

• Catalog number
  P1009-100
• Price
  Please ask
• Size
  100 ug

• Synonyms
  p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1
• Alternative_names
  p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1
• Description
  A negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Endotoxin Level
  < 1 EU/ug
• Molecular Weight
  18 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Dry powder
• Physical form description
  Lyophilized powder
• Reconstitution Instructions
  Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
• Background Information
  Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of Cyclin-Dependent Kinase Inhibitor 2A steadily increases with age, and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the Cyclin-Dependent Kinase Inhibitor 2A gene is frequently found in melanomas, as well as in certain other types of cancer. TAT is a cell penetrating peptides (CPPs) and was shown to enable the introduction of nucleic acids into cells.
• Amino acid sequence
  Full-length human Cyclin-dependent kinase inhibitor 2A and a 12-residue C-terminal TAT peptide (GYGRKKRRQRRR)
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Cyclin-dependent   kinase   inhibitor   TAT  
• Gene symbol
  TAT, TAT-AS1, HTATSF1, HTATSF1P1, TRI-TAT2-2, TRI-TAT1-1, TRI-TAT3-1, TRI-TAT2-3, TRI-TAT2-1
• Short name
  Cyclin-dependent kinase inhibitor 2A_TAT, Recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Cyclin-dependent phosphorylation catalyst suppressor 2A_TAT, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11573
• Gene
  TAT
• Long gene name
  tyrosine aminotransferase
• Locus
  16q22.2
• Discovery year
  2001-06-22
• Entrez gene record
  6898
• VEGA ID
  OTTHUMG00000137590

Gene info

• Identity
  HGNC:51369
• Gene
  TAT-AS1
• Long gene name
  TAT antisense RNA 1
• GenBank acession
  • HY017421
  • BU568247
  • BM853033
• Locus
  16q22.2
• Discovery year
  2014-10-16
• Entrez gene record
  100132529
• RefSeq identity
  • NR_103851
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000176800

Gene info

• Identity
  HGNC:5276
• Gene
  HTATSF1
• Long gene name
  HIV-1 Tat specific factor 1
• Synonyms gene name
  • HIV TAT specific factor 1
• Synonyms
  • TAT-SF1
• GenBank acession
  • U76992
• Locus
  Xq26.3
• Discovery year
  2000-07-25
• Entrez gene record
  27336
• Pubmed identfication
  • 8849451
• RefSeq identity
  • NM_014500
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000022510
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:13959
• Gene
  HTATSF1P1
• Long gene name
  HIV-1 Tat specific factor 1 pseudogene 1
• Synonyms gene
  • HTATSF1P
• Synonyms gene name
  • HIV TAT specific factor 1 pseudogene
  • HIV-1 Tat specific factor 1 pseudogene
• Synonyms
  • TAT-SF1-L
  • dJ1033B10.6
• Locus
  6p21.32
• Discovery year
  2003-11-26
• Entrez gene record
  387039
• VEGA ID
  OTTHUMG00000031101

Gene info

• Identity
  HGNC:34587
• Gene
  TRI-TAT2-2
• Long gene name
  tRNA-Ile (anticodon TAT) 2-2
• Synonyms gene
  • TRNAI2
• Synonyms gene name
  • transfer RNA isoleucine 2 (anticodon UAU)
  • transfer RNA-Ile (TAT) 2-2
• Synonyms
  • tRNA-Ile-TAT-2-2
• GenBank acession
  • HG983865
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189028
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34891
• Gene
  TRI-TAT1-1
• Long gene name
  tRNA-Ile (anticodon TAT) 1-1
• Synonyms gene
  • TRNAI18
• Synonyms gene name
  • transfer RNA isoleucine 18 (anticodon UAU)
  • transfer RNA-Ile (TAT) 1-1
• Synonyms
  • tRNA-Ile-TAT-1-1
• GenBank acession
  • HG983863
• Locus
  19q13.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189324
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34916
• Gene
  TRI-TAT3-1
• Long gene name
  tRNA-Ile (anticodon TAT) 3-1
• Synonyms gene
  • TRNAI21
• Synonyms gene name
  • transfer RNA isoleucine 21 (anticodon UAU)
  • transfer RNA-Ile (TAT) 3-1
• Synonyms
  • tRNA-Ile-TAT-3-1
• GenBank acession
  • HG983867
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189348
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34693
• Gene
  TRI-TAT2-3
• Long gene name
  tRNA-Ile (anticodon TAT) 2-3
• Synonyms gene
  • TRNAI6
• Synonyms gene name
  • transfer RNA isoleucine 6 (anticodon UAU)
  • transfer RNA-Ile (TAT) 2-3
• Synonyms
  • tRNA-Ile-TAT-2-3
• GenBank acession
  • HG983866
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189131
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34828
• Gene
  TRI-TAT2-1
• Long gene name
  tRNA-Ile (anticodon TAT) 2-1
• Synonyms gene
  • TRNAI13
• Synonyms gene name
  • transfer RNA isoleucine 13 (anticodon UAU)
  • transfer RNA-Ile (TAT) 2-1
• Synonyms
  • tRNA-Ile-TAT-2-1
• GenBank acession
  • HG983864
• Locus
  2p21
• Discovery year
  2008-08-29
• Entrez gene record
  100189265
• Classification
  • Cytoplasmic transfer RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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