Cyclin D1 Antibody

• Catalog number
  bs-0623R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Cyclin D1 Primary Polyclonal Antibody
• Also known as
  Cyclin D1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Cyclin D1
• Specificity
  This is a highly specific antibody against Cyclin D1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  70-120/295
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic peptide derived from mouse Cyclin D1
• Gene ID number
  12443
• Swiss Prot
  P25322
• Tested Applications
  WB, FCM, IHC-P, IF(IHC-P), IF(ICC)
• Recommended dilutions
  WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat, Goat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI32739; G1/S-specific cyclin-D1; Ccnd1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cyclin  
• Gene symbol
  CCND1, CCNDBP1
• Short name
  Anti-Cyclin D1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Cyclin D1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1582
• Gene
  CCND1
• Long gene name
  cyclin D1
• Synonyms gene
  • BCL1
  • D11S287E
  • PRAD1
• Synonyms gene name
  • cyclin D1 (PRAD1: parathyroid adenomatosis 1)
• Synonyms
  • U21B31
• Synonyms name
  • parathyroid adenomatosis 1
  • B-cell CLL/lymphoma 1
  • G1/S-specific cyclin D1
• GenBank acession
  • Z23022
• Locus
  11q13.3
• Discovery year
  1991-06-06
• Entrez gene record
  595
• Pubmed identfication
  • 1826542
  • 1833066
• RefSeq identity
  • NM_053056
• Classification
  • Cyclins
• VEGA ID
  OTTHUMG00000167877
• Locus Specific Databases
  • LRG_990

Gene info

• Identity
  HGNC:1587
• Gene
  CCNDBP1
• Long gene name
  cyclin D1 binding protein 1
• Synonyms gene name
  • cyclin D-type binding-protein 1
• Synonyms
  • DIP1
  • GCIP
  • HHM
• Synonyms name
  • D-type cyclin-interacting protein 1
  • MAID protein
  • grap2 and cyclin D interacting protein
• GenBank acession
  • AF082569
• Locus
  15q15.2
• Discovery year
  1998-10-02
• Entrez gene record
  23582
• Pubmed identfication
  • 10801854
• RefSeq identity
  • NM_012142
• VEGA ID
  OTTHUMG00000130703

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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