CXCR7/RDC1 Antibody, ALEXA FLUOR 488

• Catalog number
  bs-4897R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  CXCR7/RDC1 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-CXCR7/RDC1 PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  CXCR7/RDC1
• Specificity
  This is a highly specific antibody against CXCR7/RDC1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  184-213/362
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CXCR7/RDC1
• Gene ID Number
  57007
• Swiss Prot
  P25106
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159; Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; ACKR3
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-CXCR7/RDC1 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  CXCR7/RDC1  
• Gene symbol
  ACKR3, VIPR1
• Short name
  Anti-CXCR7/RDC1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  CXCR7/RDC1 Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies
• Alternative to gene target
  chemokine (C-X-C motif) receptor 7, CXCR7 and IDBG-84146 and ENSG00000144476 and 57007, C-X-C chemokine binding, Cell surfaces, Cxcr7 and IDBG-179969 and ENSMUSG00000044337 and 12778, CXCR7 and IDBG-642053 and ENSBTAG00000018424 and 509585

Gene info

• Identity
  HGNC:23692
• Gene
  ACKR3
• Long gene name
  atypical chemokine receptor 3
• Synonyms gene
  • CMKOR1
  • CXCR7
• Synonyms gene name
  • chemokine orphan receptor 1
  • chemokine (C-X-C motif) receptor 7
• Synonyms
  • RDC1
  • GPR159
• GenBank acession
  • BC008459
• Locus
  2q37.3
• Discovery year
  2003-12-01
• Entrez gene record
  57007
• Pubmed identfication
  • 16107333
  • 16148
• RefSeq identity
  • NM_020311
• Classification
  • Atypical chemokine receptors
• VEGA ID
  OTTHUMG00000133295

Gene info

• Identity
  HGNC:12694
• Gene
  VIPR1
• Long gene name
  vasoactive intestinal peptide receptor 1
• Synonyms
  • VPAC1
  • RDC1
  • HVR1
  • VPAC1R
• Synonyms name
  • VIP and PACAP receptor 1
• GenBank acession
  • AH005329
• Locus
  3p22.1
• Discovery year
  1991-09-13
• Entrez gene record
  7433
• Pubmed identfication
  • 7708752
• RefSeq identity
  • NM_004624
• Classification
  • Vasoactive intestinal peptide family receptors
• VEGA ID
  OTTHUMG00000131792

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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