CXCR3 Antibody

CXCR3 Antibody is available 1 time from Boster labs

  • Target antigen
    CXCR3
  • Clonality
    Polyclonal antibody
  • Clone
    Polyclonal antibody
  • Raised in
    rabbit
  • Type of the antibody
    IgG polyclonal antibody
  • Product form
    freeze-dried
  • Reacts with species:
    human Predicted to work with: mouse, rat
  • Analyses
    WB,IHC-P
  • Immunogen
    E.coli-derived human CXCR3 recombinant protein (Position: M1-L368). Human CXCR3 shares 86% amino acid (aa) sequence identity with both mouse and rat CXCR3.
  • Product configuration
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
  • Purification
    Immunogen affinity purified.
  • Solubilization
    The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
  • Storage condtions
    Keep the CXCR3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
  • Tips
    The CXCR3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
  • Background
    Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. It is mapped to Xq13.1. CXCR3 is expressed on malignant B cells from chronic lymphoproliferative disorders, particularly in patients with CLL, and represents a fully functional receptor involved in chemotaxis of malignant B lymphocytes. It is found that in the absence of known etiologic agents, CXCR3 represents a novel target for therapeutic interference early in type 1 diabetes. CXCR3 signaling is associated with MG pathogenesis and proposed that and CXCR3 may serve as novel drug targets to treat MG. CXCR3A and CXCR3B are involved in the chemotactic and vascular effects of CXCL4L1.
  • Related articles
    1. Trentin, L., Agostini, C., Facco, M., Piazza, F., Perin, A., Siviero, M., Gurrieri, C., Galvan, S., Adami, F., Zambello, R., Semenzato, G. The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis. J. Clin. Invest. 104: 115-121, 1999. 2. Frigerio, S., Junt, T., Lu, B., Gerard, C., Zumsteg, U., Hollander, G. A., Piali, L. Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nature Med. 8: 1414-1420, 2002. 3. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. J. Immun. 174: 5324-5331, 2005. 4. Struyf, S., Salogni, L., Burdick, M. D., Vandercappellen, J., Gouwy, M., Noppen, S., Proost, P., Opdenakker, G., Parmentier, M., Gerard, C., Sozzani, S., Strieter, R. M., Van Damme, J. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. Blood 117: 480-488, 2011.
  • Gene Name
    CXCR3
  • Protein Name
    C-X-C chemokine receptor type 3
  • Gene Full Name
    chemokine (C-X-C motif) receptor 3
  • Synonyms
    C-X-C chemokine receptor type 3 antibody|CD 183 antibody|CD182 antibody|CD183 antibody|Chemokine (C X C motif) receptor 3 antibody|Chemokine (C X C) receptor 3 antibody|Chemokine CXC Motif Receptor 3 antibody|CKR L2 antibody|CKR-L2 antibody|CKRL2 antibody|CMKAR3 antibody|CXC-R3 antibody|CXCR-3 antibody|CXCR3 antibody|CXCR3_HUMAN antibody|G Protein Coupled Receptor 9 antibody|G protein-coupled receptor 9 antibody|GPR9 antibody|Interferon-inducible protein 10 receptor antibody|IP-10 receptor antibody|IP10 antibody|IP10 R antibody|IP10 receptor antibody|IP10-R antibody|IP10R antibody|Mig R antibody|Mig receptor antibody|Mig-R antibody|MIGR antibody
  • Uniprot ID
    P49682
  • Entrez GeneID
    2833
  • Properties
    If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    CXCR3 Antibody
  • Technique
    Antibody
  • Alternative name
    chemokine (C-X-C motif) receptor 3 (Antibody to)
  • Alternative technique
    antibodies
  • Alternative to gene target
    chemokine (C-X-C motif) receptor 3, CD182 and CD183 and CKR-L2 and CMKAR3 and GPR9 and IP10-R and Mig-R and MigR, CXCR3 and IDBG-76333 and ENSG00000186810 and 2833, this GO :0001525 and angiogenesis and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0002685 and regulation of leukocyte migration and biological process this GO :0004872 and receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006928 and cellular component movement and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010818 and T cell chemotaxis and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0019956 and chemokine binding and molecular function this GO :0019958 and C-X-C chemokine binding and molecular function this GO :0030816 and positive regulation of cAMP metabolic process and biological process this GO :0043950 and positive regulation of cAMP-mediated signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050921 and positive regulation of chemotaxis and biological process this GO :0051281 and positive regulation of release of sequestered calcium ion into cytosol and biological process this GO :0071954 and chemokine (C-C motif) ligand 11 production and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :1900119 and positive regulation of execution phase of apoptosis and biological process, C-X-C chemokine binding, this GO :0004872: receptor activity and also this GO :0004930: G-protein coupled receptor activity and also this GO :0004950: chemokine receptor activity and also this GO :0016494: C-X-C chemokine receptor activity and also this GO :0019956: chemokine binding and also this GO :0019958: C-X-C chemokine binding, this GO :0004872: receptor activity, this GO :0004930: G-protein coupled receptor activity, this GO :0004950: chemokine receptor activity, this GO :0016494: C-X-C chemokine receptor activity, this GO :0019956: chemokine binding, this GO :0019958: C-X-C chemokine binding, Cell surfaces, Cxcr3 and IDBG-164788 and ENSMUSG00000050232 and 12766, CXCR3 and IDBG-635748 and ENSBTAG00000014798 and 497018

PB9079 | CXCR3 Antibodysize: 0,1 mg | 460.36 USD

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