CstF-64 Antibody
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Catalog numberbs-6995R
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PricePlease ask
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Size0.1ml
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Long nameCstF-64 Primary Polyclonal Antibody
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Also known asCstF-64 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenCstF-64
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SpecificityThis is a highly specific antibody against CstF-64.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CSTF2T/CstF-64
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Gene ID number23283
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Tested ApplicationsWB, IHC-P, IF(IHC-P)
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Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenPolyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesCF1 64 kDa subunit, tau variant; Cleavage stimulation factor 64 kDa subunit, tau variant; CSTF 64 kDa subunit, tau variant; KIAA0689; TauCstF64; CSTFT_HUMAN.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCSTF2, CSTF2T
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Short nameAnti-CstF-64
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameCstF-64 Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namecleavage stimulation factor subunit 2
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Synonyms gene name
- cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kD
- cleavage stimulation factor, 3' pre-RNA, subunit 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-12-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Cleavage stimulation factor subunits
- RNA binding motif containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namecleavage stimulation factor subunit 2 tau variant
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Synonyms gene name
- cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
- cleavage stimulation factor, 3' pre-RNA, subunit 2, tau variant
- cleavage stimulation factor subunit 2, tau variant
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-10-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RNA binding motif containing
- Cleavage stimulation factor subunits
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data