CRTC1 Antibody
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Catalog numberR31093
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenCRTC1
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB
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Recommended dilutionsWestern blot: 0.5-1ug/ml
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NotesThe stated application concentrations are suggested starting amounts. Titration of the CRTC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented useThis CRTC1 antibodyis to be used only for research purposes and not for diagnostics..
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UniprotQ6UUV9
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PurityAntigen affinity
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DescriptionCREB-Regulated Transcription Coactivator 1, also known as MECT1, TORC1 or KIAA0616, is a protein that in humans is encoded by the CRTC1 gene. By sequence analysis, Tonon et al.(2003) mapped the gene to chromosome 19p13. Kovacs et al.(2007) found that it was expressed in adult mouse brain and cultured neurons, and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways. Mair et al.(2011) demonstrated that CRTC1 is a direct AMPK target, and interacts with the CREB homolog-1(CRH1) transcription factor in vivo. The prolongevity effects of activating AMPK or deactivating calcineurin decrease CRTC1 and CRH1 activity and induce transcriptional responses similar to those of CRH1-null worms.
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ImmunogenAn amino acid sequence from the C-terminus of human CRTC1 (EQQMAARQANALSHQL) was used as the immunogen for this CRTC1 antibody.
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StorageAfter reconstitution, the CRTC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCRTC1
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Short nameAnti-CRTC1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to CRTC1
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameCREB regulated transcription coactivator 1
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Synonyms gene
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Synonyms gene name
- mucoepidermoid carcinoma translocated 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-08-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data