CRANAD-2

• Catalog number
  2699-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
• Description
  GRANAD-2 is a near-infrared Aβ plaque-specific fluorescent probe penetrating the blood brain barrier and label senile plaques specifically in vivo. Upon interacting with Aβ aggregates, CRANAD-2 displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD -2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.
• CAS Number
  1193447-34-5
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₅BF₂N₂O₂
• Molecular Weight
  410.26
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 2 mg/ml with slight warming)
• Handling
  Protect from air and light
• Tag Line
  An amyloid β (Aβ ) plaque-specific fluorescent probe
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• SMILES
  CN(C)C1=CC=C(/C=C/C(/C=C(/C=C/C2=CC=C(N(C)C)C=C2)OB(F)F)=O)C=C1>>
• InChi
  InChI=1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22(29)17-23(30-24(25)26)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+,23-17-
• InChi Key
  REYKHNSZPNPCFO-HCYHKVCZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CRANAD-2  
• Gene symbol
  MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2, KRTAP13-2, SNORD114-2, SNORD116-2
• Short name
  CRANAD-2
• Alternative name
  CRANAD-2

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

Gene info

• Identity
  HGNC:34270
• Gene
  RNU6-2
• Long gene name
  RNA, U6 small nuclear 2
• Synonyms
  • U6-2
• Locus
  19p13.3
• Discovery year
  2008-06-10
• Entrez gene record
  103625684
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_125730
• Classification
  • Small nuclear RNAs

Gene info

• Identity
  HGNC:18923
• Gene
  KRTAP13-2
• Long gene name
  keratin associated protein 13-2
• Synonyms
  • KAP13-2
• GenBank acession
  • AP001708
• Locus
  21q22.11
• Discovery year
  2003-02-21
• Entrez gene record
  337959
• Pubmed identfication
  • 12359730
• Classification
  • Keratin associated proteins
• VEGA ID
  OTTHUMG00000057793

Gene info

• Identity
  HGNC:32990
• Gene
  SNORD114-2
• Long gene name
  small nucleolar RNA, C/D box 114-2
• Synonyms
  • 14q(II-2)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767578
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003194.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33068
• Gene
  SNORD116-2
• Long gene name
  small nucleolar RNA, C/D box 116-2
• Synonyms
  • HBII-85-2
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033414
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003317
• Classification
  • Small nucleolar RNAs, C/D box

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