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Alternative_name
2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol; CRC 87-09, NSC 817373
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Description
A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/β-catenikt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation.
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CAS Number
117048-59-6
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₈H₂₀O₅
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Molecular Weight
316.35
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (100 mM) or EtOH (100 mM)
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Handling
Protect from light and moisture
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Tag Line
A vascular disrupting, antineoplastic and microtubule-depolymerizing agent.
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD03453309
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PubChem CID
5351344
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SMILES
COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
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InChi
InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
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InChi Key
HVXBOLULGPECHP-WAYWQWQTSA-N
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MSDS Available
Yes
