Colorimetric Human Lactate Dehydrogenase A Inhibitor Screening Kit

Colorimetric Human Lactate Dehydrogenase A Inhibitor Screening Kit is available 1 time from Biovision labs

  • Description
    The human oxidoreductase Lactate Dehydrogenase A (LDHA) (EC:1.1.1.27) is a key enzyme in lactic acid metabolism. It interconverts pyruvate and NADH to lactate and NAD+ respectively. In mammals, LDHA exists as a tetramer and is primarily found in skeletal muscle tissues. LDHA is a common marker to assay for tissue damage and is also known to promote tumor proliferation in breast, lung, and pancreatic cancer patients. In BioVision’s LDHA Inhibitor Screening Kit, LDHA catalyzes the conversion of lactate to an intermediate that interacts with a probe to develop a color that can be measured at OD 450 nm. In the presence of a LDHA specific inhibitor, the reaction is impeded. A LDHA Inhibitor Control is included to compare the efficacy of the sample inhibitors. The assay is high-throughput adaptable and can be completed in less than 1 hr
  • Highlights
    Simple and sensitive assay. Fast protocol - can be performed in 30 min. HTP adaptable.
  • Kit reactivity
    N/A
  • Kit is besf for
    Screening/characterizing/studying potential inhibitors of Lactate Dehydrogenase A
  • Other name
    LDH Inhibitor Screening Kit
  • Detection procedure
    Absorbance (OD = 450 nm).
  • Kit contents
    The Colorimetric Human Lactate Dehydrogenase A Inhibitor Screening Kit contains LDHA Assay Buffer, LDHA Substrate Mix, LDHA, LDHA Inhibitor Control and LDHA Dilution Buffer
  • Samples
    Small molecules
  • Assay type
    Metabolism
  • Storage
    Store this kit at -20°C for 12 months
  • Delivery
    This product is shipped with gel pack
  • Datasheet
    Please contact us to inquire the datasheet and an example certificate of analysis
  • Released
    This assay kit is on the market since May 2017
  • Properties
    Colorimetric assays or detection use UV absorption or enzymatic color reaction.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    Colorimetric Lactate Dehydrogenase A Inhibitor Screening Kit
  • Technique
    colorimetric
  • Species
    Human
  • Alternative name
    colorimetry H. sapiens Lactate Dehydrogenase A suppressor quantification reagent
  • Alternative technique
    assays
  • Alternative to gene target
    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
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