N-Trifluoroacetyl-N-methyl-deacetylcolchiceine

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Cas number

1217782-80-3
Chemical s molecular weight

453.41
Chemical s main applications

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Chemical s category

Inhibitors
Other name

2,2,2-Trifluoro-N-methyl-N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide;
Chemical s formula

C22H22F3NO6
Physical properties

Yellow Solid
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

Chloromethane, Dichlormethane, DMSO, Methanol
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications
Description

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3. In formulas, the group is often abbreviated Me. Such hydrocarbon groups occur in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, it can be found on its own in any of three forms anion, cation or radical. The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed,

Identity

HGNC:7989
Gene

NRAS
Long gene name

NRAS proto-oncogene, GTPase
Synonyms gene name
- neuroblastoma RAS viral (v-ras) oncogene homolog
- neuroblastoma RAS viral oncogene homolog
Synonyms
- N-ras
GenBank acession
- BC005219
Locus

1p13.2
Discovery year

2001-06-22
Entrez gene record

4893
Pubmed identfication
- 6705568
- 11524732
RefSeq identity
- NM_002524
Classification
- RAS type GTPase family
VEGA ID

OTTHUMG00000012059
Locus Specific Databases
- NRASbase: Mutation registry for autoimmune lymphoproliferative syndrome type IV
- LRG_92

Identity

HGNC:12735
Gene

WASL
Long gene name

WASP like actin nucleation promoting factor
Synonyms gene name
- Wiskott-Aldrich syndrome-like
- Wiskott-Aldrich syndrome like
Synonyms
- N-WASP
- NWASP
- WASPB
GenBank acession
- D88460
Locus

7q31.32
Discovery year

1998-10-14
Entrez gene record

8976
Pubmed identfication
- 9422512
- 9322739
- 23527602
RefSeq identity
- NM_003941
Classification
- Wiskott-Aldrich Syndrome protein family
VEGA ID

OTTHUMG00000157346

Identity

HGNC:16660
Gene

FERD3L
Long gene name

Fer3 like bHLH transcription factor
Synonyms gene name
- Fer3-like (Drosophila)
- Fer3-like bHLH transcription factor
Synonyms
- NATO3
- N-TWIST
- bHLHa31
GenBank acession
- AF369897
Locus

7p21.1
Discovery year

2002-12-09
Entrez gene record

222894
Pubmed identfication
- 11472856
- 12217327
Classification
- Basic helix-loop-helix proteins
VEGA ID

OTTHUMG00000090823

Identity

HGNC:18181
Gene

SHC3
Long gene name

SHC adaptor protein 3
Synonyms gene name
- src homology 2 domain containing transforming protein C3
- SHC (Src homology 2 domain containing) transforming protein 3
Synonyms
- N-Shc
- NSHC
- SHCC
GenBank acession
- D84361
Locus

9q22.1
Discovery year

2003-11-12
Entrez gene record

53358
Pubmed identfication
- 8808684
RefSeq identity
- NM_016848
Classification
- SH2 domain containing
VEGA ID

OTTHUMG00000020179