CO4, Complement component C4

• Catalog number
  IMS02-032-303
• Price
  Please ask
• Size
  100 µl (1 mg/ml)

• Available ordering format
  Liquid in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide, pH 7.2
• Immunogen
  full length native protein P0C0L4 purified from human plasma
• Raised in
  Hen
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Affinity purified IgY
• How to reconstitute
  See included datasheet or contact our support service
• Storage condition
  store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
• Verified applications
  ELISA (ELISA), Western blot (WB), immunodifusion (ID)
• Connected products
  IMS06-032-304 | anti-Complement component C4, biotinylatedIMS01-031-305 | anti-Complement component C4cIMS01-066-309 | anti-Complement factor HSecondary antibodies
• Recommended dilutions for use
  1: 2000 (ELISA), 1: 1000 with standard ECL (WB)
• Molecular weight expected аpparent
  193 kDa
• Verified reactivity
  human
• Possible reactivity
  human
• No reactivity
  no confirmed exceptions from predicted reactivity known in the moment
• Supplementary information
  Only one precipitin arc in immunodiffusion against normal human serum or human complement component C4. Only one precipitin arc in immunoelectrophoresis against normal human serum or human complement component C4.ELISA has been performed on C4 deposition using human and mouse serum.
• References
  to be added when available
• Scientific context
  Complement component C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa; beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600 mg/L. It is a protein of the classical complement pathway. When activated by C1s, peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.
• Notes
  affinity purified IgY on human C4 agarose
• Protein number
  P0C0L4
• TAIR number
  Refer to NCBI
• Hyperlink

• Gene target
  CO4   Complement   component  
• Gene symbol
  C4B, C4A
• Short name
  CO4, Complement component C4
• Alternative name
  CO4, Complement component C4

Gene info

• Identity
  HGNC:1324
• Gene
  C4B
• Long gene name
  complement C4B (Chido blood group)
• Synonyms gene name
  • complement component 4B
  • complement component 4B (Chido blood group)
• Synonyms
  • CPAMD3
  • C4F
  • CO4
  • C4B1
  • C4B3
  • CH
• GenBank acession
  • AF019413
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  721
• RefSeq identity
  • NM_001002029
• Classification
  • C3 and PZP like, alpha-2-macroglobulin domain containing
  • Blood group antigens
  • Complement system activation components
• VEGA ID
  OTTHUMG00000031187
• Locus Specific Databases
  • LRG_138

Gene info

• Identity
  HGNC:1323
• Gene
  C4A
• Long gene name
  complement C4A (Rodgers blood group)
• Synonyms gene name
  • complement component 4A
  • complement component 4A (Rodgers blood group)
• Synonyms
  • CPAMD2
  • C4S
  • CO4
  • C4
  • C4A3
  • C4A2
  • C4A4
  • C4A6
  • C4B
  • RG
• GenBank acession
  • L26261
  • M14823
  • X77491
  • AY224378
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  720
• RefSeq identity
  • NM_007293
• Classification
  • C3 and PZP like, alpha-2-macroglobulin domain containing
  • Blood group antigens
  • Complement system activation components
• VEGA ID
  OTTHUMG00000031186
• Locus Specific Databases
  • LRG_137

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