CNGB3 Antibody

• Catalog number
  R36477-100UG
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CNGB3
• Host animal
  Goat (Capra aegagrus hircus)
• Clonality
  Polyclonal (goat origin)
• Species reactivity
  Human (Homo sapiens); Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IHC-P, ELISA (peptide)
• Recommended dilutions
  IHC (FFPE): 2-4ug/ml,ELISA (peptide) LOD: 1:8000
• Notes
  Optimal dilution of the CNGB3 antibody should be determined by the researcher.
• Intented use
  This CNGB3 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9NQW8
• Purity
  Antigen affinity
• Description
  Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Cyclic nucleotide-gated cation channel beta-3 can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. [UniProt]
• Immunogen
  Amino acids ESDDKPTEHYYR were used as the immunogen for this CNGB3 antibody.
• Storage
  Aliquot and store the CNGB3 antibody at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CNGB3  
• Gene symbol
  CNGB3
• Short name
  Anti-CNGB3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Goat Ig
• Alternative name
  Antibodies to CNGB3
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2153
• Gene
  CNGB3
• Long gene name
  cyclic nucleotide gated channel subunit beta 3
• Synonyms gene
  • ACHM3
  • ACHM1
  • RMCH
• Synonyms gene name
  • achromatopsia (rod monochromacy) 3
  • achromatopsia (rod monochromacy) 1
  • cyclic nucleotide gated channel beta 3
• GenBank acession
  • AF228520
• Locus
  8q21.3
• Discovery year
  2000-07-12
• Entrez gene record
  54714
• Pubmed identfication
  • 10888875
  • 10958649
  • 16382102
• RefSeq identity
  • NM_019098
• Classification
  • Cyclic nucleotide gated channels
• VEGA ID
  OTTHUMG00000163738

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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