CIRBP / Cold-inducible RNA-binding protein, human recombinant

• Catalog number
  7589-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  A18HNRNP, CIRP, CIRBP
• Alternative_names
  A18HNRNP, CIRP, CIRBP
• Description
  Plays a protective role in the genotoxic stress response
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 1.0 EU per ug of the protein as determined by the LAL method.
• Molecular Weight
  20.5 kDa
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized
• Physical form description
  Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.25 M Imidazole, 20% glycerol.
• Reconstitution Instructions
  It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml
• Background Information
  CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator. CIRBP can bind the 3'untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CIRBP   Cold   RNA-binding   protein  
• Gene symbol
  CIRBP, CIRBP-AS1
• Short name
  CIRBP / Cold- RNA-binding protein, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. RNAs are to store at -70 C
• Species
  Human, Humans
• Alternative name
  CIRBP / Cold-inducible RNA-binding protein, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:1982
• Gene
  CIRBP
• Long gene name
  cold inducible RNA binding protein
• Synonyms gene name
  • cold inducible RNA-binding protein
• Synonyms
  • CIRP
• Synonyms name
  • Cold-inducible RNA-binding protein
  • glycine-rich RNA binding protein
• GenBank acession
  • D78134
• Locus
  19p13.3
• Discovery year
  1997-12-05
• Entrez gene record
  1153
• Pubmed identfication
  • 9434172
  • 9151692
• RefSeq identity
  • NM_001280
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000180145

Gene info

• Identity
  HGNC:28588
• Gene
  CIRBP-AS1
• Long gene name
  CIRBP antisense RNA 1
• Synonyms gene
  • C19orf23
• Synonyms gene name
  • chromosome 19 open reading frame 23
  • CIRBP antisense RNA 1 (non-protein coding)
• Synonyms
  • MGC39338
• GenBank acession
  • BC026041
• Locus
  19p13.3
• Discovery year
  2004-03-16
• Entrez gene record
  148046
• Pubmed identfication
  • 12477932
• RefSeq identity
  • NR_027271
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000180146

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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