ICOSLG /B7-H2 /CD275, mouse recombinant

  • Catalog number
    P1106-50
  • Price
    Please ask
  • Size
    50 µg
  • Synonyms
    B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
  • Alternative_names
    B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
  • Description
    Ligand for the T-cell-specific cell surface receptor ICOS
  • Recombinant
    Yes
  • Source
    CHO cells
  • Purity by SDS PAGE
    ≥95%
  • Assay
    SDS-PAGE
  • Endotoxin Level
    < 0.06 EU/ug
  • Activity Specifications test method
    Measured by its binding ability in a functional ELISA.
  • Biological activity
    Immobilized human ICOS at 1ug/ml (100ul/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0ug/ml.
  • Binding Capacity
    Immobilized human ICOS at 1ug/ml (100ul/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0ug/ml.
  • Storage Temp
    -20°C
  • Shipping
    Gel pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.2 um-filtered solution in PBS
  • Reconstitution Instructions
    Reconstitute at 100 ug/ml in sterile PBS
  • Background Information
    Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    ICOSLG   B7-H2   CD275  
  • Gene symbol
    ICOSLG, NCAPH2, TUBA3D, HHLA2, RNY4P2, LRRC23, NME2, PCDHGB7, CFB, NCR3LG1
  • Short name
    ICOSLG /B7-H2 /CD275, mouse recombinant
  • Technique
    Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Host
    mouse
  • Species
    Mouse, Mouses
  • Alternative name
    inducible T-cellular co-stimulator ligand /B7-H2 /CD275, mouse Rec.
  • Alternative technique
    rec, murine
  • Alternative to gene target
    inducible T-cell co-stimulator ligand, ICOSLG and IDBG-5107 and ENSG00000160223 and 102723996,23308, protein binding, Plasma membranes, Icosl and IDBG-168471 and ENSMUSG00000000732 and 50723, ICOSLG and IDBG-639662 and ENSBTAG00000014880 and 507857
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    RNY4 pseudogene 2
  • Synonyms gene name
    • RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
    • RNA, Ro-associated Y4 pseudogene 2
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1993-08-25
  • Entrez gene record
  • RefSeq identity
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
    CFB
  • Long gene name
    complement factor B
  • Synonyms gene
  • Synonyms gene name
    • B-factor, properdin
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1986-01-01
  • Entrez gene record
    629
  • RefSeq identity
  • Classification
    • Complement system activation components
    • Sushi domain containing
  • VEGA ID
  • Locus Specific Databases
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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