CI-1040

• Catalog number
  HY-50295
• Price
  Please ask
• Size
  200mg

• Alternative_Names
  PD 184352
• CAS
  212631-79-3
• MWt
  478.66
• Formula
  C17H14ClF2IN2O2
• Solubility
  DMSO: ≥ 150 mg/mL
• Clinical_Information
  Phase 2
• Pathway
  MAPK/ERK Pathway
• Target
  MEK
• Datasheet
• SDS

• Gene target
  CI-1040  
• Gene symbol
  NDUFV3, NDUFA5, NDUFV2, NDUFA10, NDUFS6, NDUFV1, NDUFS1, NDUFS2, NDUFB2, NDUFS5
• Short name
  CI-1040
• Alternative name
  CI-1040

Gene info

• Identity
  HGNC:7719
• Gene
  NDUFV3
• Long gene name
  NADH:ubiquinone oxidoreductase subunit V3
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) flavoprotein 3 (10kD)
  • NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
• Synonyms
  • CI-10k
• Synonyms name
  • complex I 10kDa subunit
• Locus
  21q22.3
• Discovery year
  1994-09-07
• Entrez gene record
  4731
• Pubmed identfication
  • 9344673
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000086823

Gene info

• Identity
  HGNC:7688
• Gene
  NDUFA5
• Long gene name
  NADH:ubiquinone oxidoreductase subunit A5
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (13kD, B13)
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
• Synonyms
  • B13
  • NUFM
  • CI-13KD-B
  • UQOR13
  • CI-13kB
• Synonyms name
  • complex I 13kDa subunit B
  • ubiquinone reductase
  • type I dehydrogenase
  • NADH-ubiquinone oxidoreductase 13 kDa-B subunit
• Locus
  7q31.32
• Discovery year
  1996-08-30
• Entrez gene record
  4698
• Pubmed identfication
  • 9763677
  • 9021153
• RefSeq identity
  • NM_005000
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000157348

Gene info

• Identity
  HGNC:7717
• Gene
  NDUFV2
• Long gene name
  NADH:ubiquinone oxidoreductase core subunit V2
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) flavoprotein 2 (24kD)
  • NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
• Synonyms
  • CI-24k
• Synonyms name
  • complex I 24kDa subunit
  • NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
• GenBank acession
  • X84421
• Locus
  18p11.22
• Discovery year
  1994-09-07
• Entrez gene record
  4729
• Pubmed identfication
  • 9763677
  • 7607668
• RefSeq identity
  • NM_021074
• Classification
  • NADH:ubiquinone oxidoreductase core subunits
• VEGA ID
  OTTHUMG00000131593

Gene info

• Identity
  HGNC:7684
• Gene
  NDUFA10
• Long gene name
  NADH:ubiquinone oxidoreductase subunit A10
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (42kD)
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
• Synonyms
  • CI-42k
• Synonyms name
  • complex I 42kDa subunit
• GenBank acession
  • AF087661
• Locus
  2q37.3
• Discovery year
  1997-12-17
• Entrez gene record
  4705
• Pubmed identfication
  • 9878551
• RefSeq identity
  • NM_004544
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000133350

Gene info

• Identity
  HGNC:7713
• Gene
  NDUFS6
• Long gene name
  NADH:ubiquinone oxidoreductase subunit S6
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 6 (13kD) (NADH-coenzyme Q reductase)
  • NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
• Synonyms
  • CI-13kA
• Synonyms name
  • complex I 13kDa subunit A
  • NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
• GenBank acession
  • BC038664
• Locus
  5p15.33
• Discovery year
  1995-11-08
• Entrez gene record
  4726
• Pubmed identfication
  • 9763677
• RefSeq identity
  • NM_004553
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000090372

Gene info

• Identity
  HGNC:7716
• Gene
  NDUFV1
• Long gene name
  NADH:ubiquinone oxidoreductase core subunit V1
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) flavoprotein 1 (51kD)
  • NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
• Synonyms
  • CI-51K
• Synonyms name
  • complex I 51kDa subunit
  • NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
• GenBank acession
  • AF092131
• Locus
  11q13.2
• Discovery year
  1993-07-09
• Entrez gene record
  4723
• Pubmed identfication
  • 1478657
• RefSeq identity
  • NM_007103
• Classification
  • NADH:ubiquinone oxidoreductase core subunits
• VEGA ID
  OTTHUMG00000166215

Gene info

• Identity
  HGNC:7707
• Gene
  NDUFS1
• Long gene name
  NADH:ubiquinone oxidoreductase core subunit S1
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 1 (75kD) (NADH-coenzyme Q reductase)
  • NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
• Synonyms
  • CI-75k
• Synonyms name
  • complex I 75kDa subunit
  • NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
• Locus
  2q33.3
• Discovery year
  1992-04-03
• Entrez gene record
  4719
• Pubmed identfication
  • 1935949
• RefSeq identity
  • NM_005006
• Classification
  • NADH:ubiquinone oxidoreductase core subunits
• VEGA ID
  OTTHUMG00000132892

Gene info

• Identity
  HGNC:7708
• Gene
  NDUFS2
• Long gene name
  NADH:ubiquinone oxidoreductase core subunit S2
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 2 (49kD) (NADH-coenzyme Q reductase)
  • NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
• Synonyms
  • CI-49
• Synonyms name
  • complex I 49kDa subunit
  • NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
• GenBank acession
  • BC008868
• Locus
  1q23.3
• Discovery year
  1992-06-30
• Entrez gene record
  4720
• Pubmed identfication
  • 1832859
  • 9585441
• RefSeq identity
  • NM_004550
• Classification
  • NADH:ubiquinone oxidoreductase core subunits
• VEGA ID
  OTTHUMG00000034344

Gene info

• Identity
  HGNC:7697
• Gene
  NDUFB2
• Long gene name
  NADH:ubiquinone oxidoreductase subunit B2
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 (8kD, AGGG)
  • NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
• Synonyms
  • AGGG
  • CI-AGGG
• Synonyms name
  • NADH-ubiquinone oxidoreductase AGGG subunit
  • complex I AGGG subunit
• GenBank acession
  • AF050639
• Locus
  7q34
• Discovery year
  1996-11-15
• Entrez gene record
  4708
• Pubmed identfication
  • 9763677
  • 9878551
• RefSeq identity
  • NM_004546
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000157424

Gene info

• Identity
  HGNC:7712
• Gene
  NDUFS5
• Long gene name
  NADH:ubiquinone oxidoreductase subunit S5
• Synonyms gene name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 5 (15kD) (NADH-coenzyme Q reductase)
  • NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
• Synonyms
  • CI-15k
• Synonyms name
  • complex I 51kDa subunit
  • NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
• GenBank acession
  • AF047434
• Locus
  1p34.3
• Discovery year
  1995-11-08
• Entrez gene record
  4725
• Pubmed identfication
  • 9763677
  • 9653160
• RefSeq identity
  • NM_004552
• Classification
  • NADH:ubiquinone oxidoreductase supernumerary subunits
• VEGA ID
  OTTHUMG00000007497

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