CHMP1A Antibody

• Catalog number
  bs-4207R
• Price
  Please ask
• Size
  0.1ml

• Long name
  CHMP1A Primary Polyclonal Antibody
• Also known as
  CHMP1A PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  CHMP1A
• Specificity
  This is a highly specific antibody against CHMP1A.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  70-120/196
• Subcellular location
  Cytoplasm, Nucleus, Cell membrane
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CHMP1A
• Gene ID number
  5119
• Swiss Prot
  Q9HD42
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  PCH8; CHMP1; PRSM1; PCOLN3; VPS46A; VPS46-1; Charged multivesicular body protein 1a; Chromatin-modifying protein 1a; CHMP1a; Vacuolar protein sorting-associated protein 46-1; hVps46-1; KIAA0047
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CHMP1A  
• Gene symbol
  CHMP1A
• Short name
  Anti-CHMP1A
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  CHMP1A Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8740
• Gene
  CHMP1A
• Long gene name
  charged multivesicular body protein 1A
• Synonyms gene
  • PRSM1
  • PCOLN3
• Synonyms gene name
  • procollagen (type III) N-endopeptidase
  • chromatin modifying protein 1A
• Synonyms
  • KIAA0047
  • CHMP1
  • Vps46A
• GenBank acession
  • U58048
• Locus
  16q24.3
• Discovery year
  1993-05-03
• Entrez gene record
  5119
• Pubmed identfication
  • 11559748
  • 11559747
• RefSeq identity
  • NM_002768
• Classification
  • ESCRT-III associated factors
  • Charged multivesicular body proteins
• VEGA ID
  OTTHUMG00000169521

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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