CHK1 (AF7H4) Monoclonal Antibody

• Catalog number
  bsm-50374M
• Price
  Please ask
• Size
  0.1ml

• Long name
  CHK1 (AF7H4) Monoclonal Antibody
• Also known as
  CHK1 (AF7H4) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  CHK1
• Specificity
  This is a highly specific antibody against CHK1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  AF7H4
• Concentration
  2ug/ul
• Source
  Recombinant human protein purified from E.coli (His-CHK1)
• Gene ID number
  1111
• Swiss Prot
  O14757
• Tested Applications
  WB, IP
• Recommended dilutions
  WB (2.0 ug/ml) IP (2.0 ug)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Check point kinase 1 (Chk1) is a serine / threonine protein kinase and a key mediator in the DNA damage-induced checkpoint network. Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of Chk1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, Chk1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
• Purification method
  Purified by Protein G.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CHK1; Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1; CHEK1
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CHK1   AF7H4   Monoclonal  
• Gene symbol
  CHEK1
• Short name
  Anti-CHK1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)1 κ
• Alternative name
  CHK1 (AF7H4) Monoclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1925
• Gene
  CHEK1
• Long gene name
  checkpoint kinase 1
• Synonyms gene name
  • CHK1 (checkpoint, S.pombe) homolog
  • CHK1 checkpoint homolog (S. pombe)
• Synonyms
  • CHK1
• GenBank acession
  • AF016582
  • BC017575
• Locus
  11q24.2
• Discovery year
  1998-04-21
• Entrez gene record
  1111
• Pubmed identfication
  • 9278511
  • 9382850
• RefSeq identity
  • NM_001274
• VEGA ID
  OTTHUMG00000165853

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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