CHIR99021, GSK3β kinase inhibitor

  • Catalog number
    SIH-437-1MG
  • Price
    Please ask
  • Size
    1 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    252917-06-9
  • Description
    GSK3β kinase inhibitor
  • Molecular weight
    465,3 g/mol
  • Primary research fields
    Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    CT99021 , 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C22H18Cl2N8
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (HPLC)
  • Soluble in
    Soluble to 20 mM in DMSO
  • Physical appearance
    White to light brown solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Acute toxicity, Oral (Category 2), H300 Skin irritation (Category 2), H315 Eye irritation(Category 2A), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300 Fatal if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well - ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
  • PubChem number
    9956119
  • Scientific context
    CHIR99021 is a potent and highly selective glycogen synthase kinase 3 (GSK-3) inhibitor. It also promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization.
  • Bibliography
    1. Ye S., et al. (2012) PloS One 7(4): e35892. 2. Ring D. B., et al. (2003). Diabetes. 52(3): 588–595.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of CHIR99021 (SIH-437), a GSK3beta kinase inhibitor. CAS #: 252917-06-9. Molecular Formula: C22H18Cl2N8. Molecular Weight: 465.3 g/mol. Chemical structure of CHIR99021, a GSK3beta kinase inhibitor (SIH-437). CAS # 252917-06-9. Molecular Formula: C22H18Cl2N8.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.001
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    CHIR99021, GSK3β kinase inhibitor
  • Alternative name
    CHIR99021, GSK3β phosphorylation catalyst suppressor
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