CHIR 99021 trihydrochloride

Alternative_name

6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile trihydrochloride; CT99022
Description

CHIR99021 trihydrochloride is the hydrochloride salt of the potent and highly selective glycogen synthase kinase-3β (GSK-3β) inhibitor CHIR99021 (Cat. No. 1677).
CAS Number

1782235-14-6
Structure Available

Yes
Salt Form

HCl
Molecular Formula

C₂₂H₁₈Cl₂N₈. 3HCl
Molecular Weight

574.72
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~25 mg/ml) or H₂O (>5 mg/ml)
Handling

Protect from air and moisture
Tag Line

A GSK-3β inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
SMILES

CC1=CNC(C(C(C2=CC=C(Cl)C=C2Cl)=N3)=CN=C3NCCNC4=NC=C(C#N)C=C4)=N1.[H]Cl.[H]Cl.[H]Cl
InChi

InChI=1S/C22H18Cl2N8.3ClH/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19;;;/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32);3*1H
InChi Key

DSFVSCNMMZRCIA-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes