CHAC1 Polyclonal Antibody

• Catalog number
  CAC07471
• Price
  Please ask
• Size
  50 μg

• Other name
  Glutathione-specific gamma-glutamylcyclotransferase 11 Publication,CHAC11,Blocks Notch protein1
• Immunogen
  Recombinant human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA)
• Verified reactivity
  Human, Mouse
• Verified applications
  ELISA,WB,IHC. Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  Q9BUX1
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Caprylic Acid Ammonium Sulfate Precipitation Purified
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  CHAC1  
• Gene symbol
  CHAC1
• Short name
  CHAC1 Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  ChaC, cation transport regulator homolog 1 (E. coli) polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies
• Alternative to gene target
  ChaC, cation transport regulator homolog 1 (E. coli), CHAC1 and IDBG-6874 and ENSG00000128965 and 79094, protein binding, Cytoplasm, Chac1 and IDBG-199330 and ENSMUSG00000027313 and 69065, CHAC1 and IDBG-646277 and ENSBTAG00000010371 and 505991

Gene info

• Identity
  HGNC:28680
• Gene
  CHAC1
• Long gene name
  ChaC glutathione specific gamma-glutamylcyclotransferase 1
• Synonyms gene name
  • ChaC, cation transport regulator homolog 1 (E. coli)
• Synonyms
  • MGC4504
• Synonyms name
  • gamma-GCT acting on glutathione homolog 1
• GenBank acession
  • BC019625
• Locus
  15q15.1
• Discovery year
  2005-10-25
• Entrez gene record
  79094
• Pubmed identfication
  • 23070364
• RefSeq identity
  • NM_024111
• VEGA ID
  OTTHUMG00000130208

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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