CELF2 Polyclonal Antibody

• Catalog number
  CAC07980
• Price
  Please ask
• Size
  100 μg

• Other name
  CUGBP Elav-like family member 2,CELF-2,Bruno-like protein 3,CUG triplet repeat RNA-binding protein 2,CUG-BP2,CUG-BP- and ETR-3-like factor 2,ELAV-type RNA-binding protein 3,ETR-3,Neuroblastoma apoptosis-related RNA-binding protein,hNAPOR,RNA-binding protein BRUNOL-3,CELF2,BRUNOL3,CUGBP2,ETR3,NAPOR
• Immunogen
  Recombinant Human CUGBP Elav-like family member 2 protein (291-381AA)
• Verified reactivity
  Human
• Verified applications
  ELISA,WB,IHC,IF. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200,IF:1:50-1:200
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  O95319
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Protein G purified, >95%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity).
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  CELF2  
• Gene symbol
  CELF2-DT, CELF2-AS2, CELF2-AS1, CELF2
• Short name
  CELF2 Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  CELF2 polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:54157
• Gene
  CELF2-DT
• Long gene name
  CELF2 divergent transript
• Locus
  10p14
• Discovery year
  2018-12-10
• Entrez gene record
  101928322
• RefSeq identity
  • NR_120637
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:44703
• Gene
  CELF2-AS2
• Long gene name
  CELF2 antisense RNA 2
• Locus
  10p14
• Discovery year
  2012-12-05
• Entrez gene record
  439950
• RefSeq identity
  • NR_046108
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000017665

Gene info

• Identity
  HGNC:23515
• Gene
  CELF2-AS1
• Long gene name
  CELF2 antisense RNA 1
• Synonyms gene
  • C10orf31
• Synonyms gene name
  • chromosome 10 open reading frame 31
  • CELF2 antisense RNA 1 (non-protein coding)
• Synonyms
  • FLJ40494
  • Em:AC026887.2
• GenBank acession
  • AK097813
• Locus
  10p14
• Discovery year
  2004-05-27
• Entrez gene record
  414196
• RefSeq identity
  • XR_109007
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000017669

Gene info

• Identity
  HGNC:2550
• Gene
  CELF2
• Long gene name
  CUGBP Elav-like family member 2
• Synonyms gene
  • CUGBP2
• Synonyms gene name
  • CUG triplet repeat, RNA-binding protein 2
  • CUG triplet repeat, RNA binding protein 2
  • CUGBP, Elav-like family member 2
• Synonyms
  • Etr-3
  • NAPOR-2
  • BRUNOL3
• GenBank acession
  • U69546
• Locus
  10p14
• Discovery year
  1999-12-02
• Entrez gene record
  10659
• Pubmed identfication
  • 7869393
  • 9887331
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000017668

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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