Celastrol, Proteasome inhibitor

  • Catalog number
    SIH-333-10MG
  • Price
    Please ask
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    34157-83-0
  • Description
    Proteasome inhibitor
  • Molecular weight
    450,6 g/mol
  • Primary research fields
    Cancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
  • Other name
    3-​hydroxy-​9β,​13α-​dimethyl-​2-​oxo-​24,​25,​26-​trinoroleana-​1(10),​3,​5,​7-​tetraen-​29-​oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C29H38O4
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol
  • Physical appearance
    Red Powder
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Toxic- Toxic Material Causing Immediate and Serious Toxic Effects Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H301 – Toxic if swallowed Precautionary Statements: P301 + P31 – If Swallowed, immediately call a POISON CENTER or doctor.
  • PubChem number
    122724
  • Scientific context
    Displays potent antioxidant and anti-inflammatory activity. Inhibits NFB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. It inhibits 20S proteasome chymotrypsin activity (IC50=2.5 M). Cell permeable.
  • Bibliography
    1. Sethi G., et al. (2007) Blood109: 2727. 2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053. 3. Yang H., et al. (2006) Cancer Res. 66: 4758.
  • Release date
    6-Jun-2012
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Celastrol (SIH-333), a Proteasome inhibitor. CAS #: 34157-83-0. Molecular Formula: C29H38O4. Molecular Weight: 450.6 g/mol. Chemical structure of Celastrol, a Proteasome inhibitor (SIH-333). CAS # 34157-83-0. Molecular Formula: C29H38O4.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    Celastrol, Proteasome inhibitor
  • Alternative name
    Celastrol, protein degradation aggregate suppressor
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