CDKN2A (Ser8) Antibody, ALEXA FLUOR 350

• Catalog number
  bs-5255R-A350
• Price
  Please ask
• Size
  100ul

• Long name
  CDKN2A (Ser8) Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
• Also known as
  Anti-CDKN2A Ser8 PAb ALEXA FLUOR 350
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 350
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  CDKN2A Ser8
• Specificity
  This is a highly specific antibody against CDKN2A Ser8.
• Modification
  Phosphorylation
• Modification Site
  Ser8
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human CDKN2A around the phosphorylation site of Ser8 [GS(p-S)ME]
• Gene ID Number
  1029
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  343nm/442nm
• Synonyms
  p-CDKN2A/p16-INK4aSer8; p-p16-INK4aSer8; cyclin-dependent kinase inhibitor 2A;CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A, isoform 1; Cyclin dependent kinase inhibitor 2A p16, inhibits CDK4; cell cycle inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a; cell cycle regulator; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 2; Cdkn2a; Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF; CD2A1_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 350
• French translation
  anticorps

• Gene target
  CDKN2A   Ser8  
• Gene symbol
  CDKN2A-DT, CDKN2A
• Short name
  Anti-CDKN2A Ser8
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 350
• Alternative name
  CDKN2A (Ser8) Polyclonal Antibody, ALEXA FLUOR 350
• Alternative technique
  antibodies
• Alternative to gene target
  cyclin-dependent kinase inhibitor 2A, ARF and CDK4I and CDKN2 and CMM2 and INK4 and INK4A and MLM and MTS-1 and MTS1 and P14 and P14ARF and P16 and P16-INK4A and P16INK4 and P16INK4A and P19 and P19ARF and TP16, CDKN2A and IDBG-54547 and ENSG00000147889 and 1029, MDM2/MDM4 family protein binding, nuclei, CDKN2A and IDBG-630043 and ENSBTAG00000034220 and 616369

Gene info

• Identity
  HGNC:23831
• Gene
  CDKN2A-DT
• Long gene name
  CDKN2A divergent transcript
• Synonyms gene
  • C9orf53
  • CDKN2A-AS1
• Synonyms gene name
  • chromosome 9 open reading frame 53
  • CDKN2A antisense RNA 1 (head to head)
• Synonyms
  • bA149I2.3
• GenBank acession
  • AF211119
• Locus
  9p21.3
• Discovery year
  2004-07-23
• Entrez gene record
  51198
• RefSeq identity
  • NR_024274
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000019687

Gene info

• Identity
  HGNC:1787
• Gene
  CDKN2A
• Long gene name
  cyclin dependent kinase inhibitor 2A
• Synonyms gene
  • CDKN2
  • MLM
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
• Synonyms
  • CDK4I
  • p16
  • INK4a
  • MTS1
  • CMM2
  • ARF
  • p19
  • p14
  • INK4
  • p16INK4a
  • p19Arf
  • p14ARF
• GenBank acession
  • L27211
• Locus
  9p21.3
• Discovery year
  1994-05-19
• Entrez gene record
  1029
• Pubmed identfication
  • 8152487
  • 7606716
• RefSeq identity
  • NM_000077
• VEGA ID
  OTTHUMG00000019686
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_11

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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