CDKN1A (Thr145) Antibody
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Catalog numberbs-5237R
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PricePlease ask
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Size0.1ml
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Long nameCDKN1A (Thr145) Primary Polyclonal Antibody
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Also known asCDKN1A (Thr145) PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenCDKN1A Thr145
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SpecificityThis is a highly specific antibody against CDKN1A Thr145. This phosphorylation site is homologous to that of Thr140 in Mouse and Thr145 is Rat.
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Modification sPhosphorylation
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Modification site sThr145
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range96-146/164
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Subcellular locationCytoplasm, Nucleus
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SourceKLH conjugated synthetic phosphopeptide derived from human CDKN1A around the phosphorylation site of Thr145 [RQ(p-T)S]
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Gene ID number1026
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Swiss ProtP38936
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Tested ApplicationsIHC-P, IF(IHC-P)
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Recommended dilutionsIHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenMay be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesP21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; CDKN1A; MDA6; PIC1
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCDKN1A-AS1, CDKN1A
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Short nameAnti-CDKN1A Thr145
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameCDKN1A (Thr145) Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targetcyclin-dependent kinase inhibitor 1A (p21, Cip1), CAP20 and CDKN1 and CIP1 and MDA-6 and P21 and p21CIP1 and SDI1 and WAF1, CDKN1A and IDBG-85033 and ENSG00000124762 and 1026, metal ion binding, nuclei, Cdkn1a and IDBG-159848 and ENSMUSG00000023067 and 12575, CDKN1A and IDBG-630156 and ENSBTAG00000008353 and 513497
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Gene info
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Identity
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Gene
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Long gene nameCDKN1A antisense RNA 1
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Synonyms gene name
- CDKN1A antisense RNA 1 (non-protein coding)
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Synonyms
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GenBank acession
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Locus
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Discovery year2011-07-11
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Entrez gene record
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Pubmed identfication
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene namecyclin dependent kinase inhibitor 1A
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Synonyms gene
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Synonyms gene name
- cyclin-dependent kinase inhibitor 1A (p21, Cip1)
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-05-24
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Entrez gene record
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data