cdk4 (AF10A4) Monoclonal Antibody

• Catalog number
  bsm-50350M
• Price
  Please ask
• Size
  0.1ml

• Long name
  cdk4 (AF10A4) Monoclonal Antibody
• Also known as
  cdk4 (AF10A4) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  cdk4
• Specificity
  This is a highly specific antibody against cdk4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  AF10A4
• Source
  Recombinant human protein purified from E.coli (MBP-CDK4 1-303 a.a.))
• Gene ID number
  1019
• Swiss Prot
  P11802
• Tested Applications
  WB
• Recommended dilutions
  WB (1:2,000)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
• Purification method
  Ammonium sulfate precipitation
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  CMM3; PSK-J3; Cyclin-dependent kinase 4; Cell division protein kinase 4; CDK4
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  cdk4   AF10A4   Monoclonal  
• Short name
  Anti-cdk4
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)2a κ
• Alternative name
  cdk4 (AF10A4) Monoclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  cyclin-dependent kinase 4, CMM3 and PSK-J3, CDK4 and IDBG-43642 and ENSG00000135446 and 1019, transferase activity, nuclei, Cdk4 and IDBG-194056 and ENSMUSG00000006728 and 102641469,12567

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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