CD49c / Integrin alpha 3 monoclonal antibody
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Catalog number11-137-C100
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PricePlease ask
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Size100ug
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Long nameMouse Monoclonal Antibody against Human CD49c / Integrin alpha 3, Clone: ASC-1
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AntigenCD49c / Integrin alpha 3
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Species reactivityHuman (Homo sapiens)
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Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
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ClonalityMonoclonal Antibody (Mab)
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CloneASC-1
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ApplicationsFC, IP, WB, IHC(F)
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ImmunogenHuman SSC-9 cell line (squamous cell carcinoma)
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Format conjugationpurified; unconjugated
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SpecificityThe mouse monoclonal antibody ASC-1 recognizes CD49c (integrin alpha 3), a transmembrane glycoprotein composed of disulfide linked 125 kDa and 30 kDa chains, and expressed on adherent cell lines and to a lesser extent on T and B cells and monocytes._x000D_ _x000D_ HLDA VI; WS Code A002
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Research areaCD and Related Antigens (Human)
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Concentration1 mg/ml
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Storage bufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Shipping and storageMouse Monoclonal Antibody against Human CD49c / Integrin alpha 3, Clone: ASC-1 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
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BackgroundCD49c / Integrin alpha 3 is a type I transmembrane glycoprotein proteolytically cleaved into two disulfide linked chains. It noncovalently associates with CD29 (integrin beta 1) to form the VLA-3 complex, an adhesion receptor for extracellular matrix components (fibronectin, laminin 1, laminin 5, entactin, and collagen). It is expressed on adherent cells, mainly on fibroblasts, epithelial cells and endothelial cells.
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Purity> 95% (by SDS-PAGE)
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Purification methodPurified by protein-A affinity chromatography
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References*Skubitz AP, Bast RC, Wayner EA, Letourneau PC, Wilke MS: Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am J Pathol. 1996 May;148(5):1445-61., *Pattaramalai S, Skubitz KM, Skubitz AP: A novel recognition site on laminin for the alpha 3 beta 1 integrin. Exp Cell Res. 1996 Feb 1;222(2):281-90.
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DescriptionThe Anti-CD49c / Integrin alpha 3 Mab is a α- or alpha protein sometimes glycoprotein present in blood.
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PropertiesIf you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translationanticorps
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Gene target
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Gene symbolITGA3
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Short nameAnti-CD49c / Integrin alpha 3 Mab
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TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
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HostMouse (Mus musculus)
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IsotypeIgG1
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Alternative nameMouse Monoclonal to CD49c / Integrin alpha 3
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameintegrin subunit alpha 3
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody J143
- integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-02-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Integrin alpha subunits
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data