CD46 Antibody

• Catalog number
  F48870-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CD46
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IHC, FACS, IF, WB, ELISA
• Recommended dilutions
  Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
• Notes
  Titration of the CD46 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This CD46 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P15529
• Purity
  Antigen affinity
• Description
  CD46 is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system.
• Immunogen
  A portion of amino acids 317-343 from the human protein was used as the immunogen for this CD46 antibody.
• Storage
  Aliquot the CD46 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD46  
• Gene symbol
  CD46
• Short name
  Anti-CD46
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to CD46
• Alternative technique
  antibodies
• Alternative to gene target
  CD46 molecule, complement regulatory protein, AHUS2 and MCP and MIC10 and TLX and TRA2.10, CD46 and IDBG-106372 and ENSG00000117335 and 4179, cadherin binding, Cell surfaces, Cd46 and IDBG-209330 and ENSMUSG00000016493 and 17221, BT.68611 and IDBG-638462 and ENSBTAG00000005397 and 280851

Gene info

• Identity
  HGNC:6953
• Gene
  CD46
• Long gene name
  CD46 molecule
• Synonyms gene
  • MIC10
  • MCP
• Synonyms gene name
  • antigen identified by monoclonal antibody TRA-2-10
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • CD46 antigen, complement regulatory protein
  • CD46 molecule, complement regulatory protein
• Synonyms
  • TRA2.10
  • MGC26544
  • TLX
• GenBank acession
  • BC030594
• Locus
  1q32.2
• Discovery year
  1988-08-31
• Entrez gene record
  4179
• Pubmed identfication
  • 7929741
• RefSeq identity
  • NM_172361
• Classification
  • Sushi domain containing
  • Complement system regulators and receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000036397
• Locus Specific Databases
  • LRG_155

MeSH Data

• Name
  CD4 Lymphocyte Count
• Concept
  Scope note: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
• Tree numbers
  • E01.370.225.500.195.107.595.500.150
  • E01.370.225.625.107.595.500.150
  • E05.200.500.195.107.595.500.150
  • E05.200.625.107.595.500.150
  • E05.242.195.107.595.500.150
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products