UBE3A/E6-AP Antibody, Cy3 Conjugated

  • Catalog number
    bs-11776R-Cy3
  • Price
    Please ask
  • Size
    0.1ml
  • Long name
    UBE3A/E6-AP Polyclonal Antibody, Cy3 Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    Cy3
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    UBE3A/E6-AP
  • Specificity
    This is a highly specific antibody against UBE3A/E6-AP.
  • Modification
    Unmodified
  • Modification site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic peptide derived from human UBE3A/E6-AP
  • Gene ID number
    7337
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    E6-associating protein is a component of the ubiquitin-mediated proteolytic pathway, which selectively targets proteins for degradation by the 26S proteasome. Ubiquitin (Ub) is directly conjugated to protein substrates by the transfer of Ub from an E2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such as E6-AP. Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, HHR23A. Previous studies have indicated that E6-AP associates with the human papillomavirus E6 oncogene, which complexes with p53 and thereby potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and, in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe motor dysfunction and mental retardation.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    512,550nm/570,615nm
  • Synonyms
    ANCR; Angelman syndrome; AS; CTCL tumor antigen se37 2; E6 AP; E6AP antibody E6AP ubiquitin protein ligase; E6AP ubiquitin protein ligase; E6AP ubiquitin-protein ligase; EPVE6AP; HPVE6A; Human papilloma virus E6 associated protein Angelman syndrome; Human papilloma virus E6 associated protein; Human papillomavirus E6-associated protein; NY REN 54 antigen; NY REN 54 antigen; Oncogenic protein associated protein E6 AP; Oncogenic protein associated protein E6AP; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY REN 54; Renal carcinoma antigen NY-REN-54; UBE 3A; Ube3a; UBE3A protein; UBE3A_HUMAN; Ubiquitin protein ligase E3A; Ubiquitin-protein ligase E3A.
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-UBE3A/E6-AP can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
  • Additional conjugation
    cy3 conjugation kit
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    UBE3A, SNHG14, JUND, TFAP2A, TFAP2E, PTPRCAP, AP5B1, TFAP2B, KLF12, TRRAP
  • Short name
    Anti-UBE3A/E6-AP
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Isotype
    Immunoglobulin G (IgG)
  • Label
    AP
  • Alternative name
    Anti-UBE3A/E6-AP PAb Cy3
  • Alternative technique
    antibodies
  • Alternative to gene target
    ubiquitin protein ligase E3A, ANCR and AS and E6-AP and EPVE6AP and HPVE6A, UBE3A and IDBG-4274 and ENSG00000114062 and 7337, ligase activity, nuclei, Ube3a and IDBG-190437 and ENSMUSG00000025326 and 22215, UBE3A and IDBG-628537 and ENSBTAG00000002487 and 100335247,533136
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    transcription factor AP-2 alpha
  • Synonyms gene
  • Synonyms gene name
    • transcription factor AP-2 alpha (activating enhancer-binding protein 2 alpha)
    • transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1991-09-12
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Transcription factor AP-2 family
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    transcription factor AP-2 epsilon
  • Synonyms gene name
    • transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2004-11-05
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Transcription factor AP-2 family
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    adaptor related protein complex 5 subunit beta 1
  • Synonyms gene name
    • adaptor-related protein complex 5, beta 1 subunit
    • adaptor related protein complex 5 beta 1 subunit
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2012-02-27
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Adaptor related protein complex 5
    • Armadillo like helical domain containing
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    transcription factor AP-2 beta
  • Synonyms gene name
    • transcription factor AP-2 beta (activating enhancer-binding protein 2 beta)
    • transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1995-12-18
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Transcription factor AP-2 family
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    transformation/transcription domain associated protein
  • Synonyms gene name
    • transformation/transcription domain-associated protein
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1998-10-06
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • MicroRNA protein coding host genes
    • SAGA complex
    • Armadillo like helical domain containing
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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