CD15/ Lewis X antigen/ alpha-(1 antibody3)-fucosyltransferase 4

  • Catalog number
    MUB0367P
  • Price
    Please ask
  • Size
    0,1mg
  • Category
    Primary Antibodies
  • Long description
    CD15 is a carbohydrate that is referred to as the Lewis X antigen, also known as alpha-(1,3)-fucosyltransferase 4, which is expressed on a variety of glycolipids and glycoproteins found on the cell surface of neutrophils, monocytes, eosinophils and non-hematopoietic tissues including embryonic tissues. CD15 is reported to function as an adhesion molecule and is involved in chemotaxis and phagocytosis. Expression of CD15 is also associated with a wide variety of tumour cells including some adenocarcinomas and certain types of myeloid and lymphoid leukaemias. Reed-Sternberg cells, found in cases of Hodgkins Lymphoma, also express CD15 and antibodies recognising the CD15 antigen are often used to help differentiate between Hodgkins and non-Hodgkins lymphoma.
  • Antibody come from
    BRA4F1 is a mouse IgM monoclonal antibody derived from the fusion of SP2.0-Ag14 mouse myeloma cells with splenocytes from a BALB/c mouse immunized with K562 cells.
  • Other description
    Each vial contains 100 µl 1mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide. The product is delivered in lyophilised format.
  • Clone
    BRA4F1
  • Antigen antibody binding interaction
    CD15/ Lewis X antigen/ alpha-(1 antibody3)-fucosyltransferase 4 Antibody
  • Antibody is raised in
    Mouse
  • Antibody s reacts with
    Human
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    The antibody BRA4F1 is directed against human CD15. The antibody does not cross react with the sialylated form of CD15 (CD15s).
  • Research interest
    CD markers, Cancer, Cell adhesion, Immunology
  • Application
    Flow cytometry, Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Immunocytochemistry
  • Antibody s suited for
    The BRA4F1 antibody is suitable for the detection of CD15 by flow cytometry, immunocytochemisty and immunohistochemistry of frozen and paraffin embedded tissues. Optimal antibody dilutions for the different applications should be determined by titration.
  • Storage
    Store at 4oC, or in small aliquots at -20oC.
  • Relevant references
    Chorváth B , Sedlák J, Suliková M, Plesková I, Augustínová M, Duraj J. Monoclonal antibodies (series Bra-) of broad (non-lineage) or restricted (myelomonocytic) reactivities elicited with granulocytes or K 562 cells. Neoplasma. 1989;36(6):633-42. 2. CD15 workshop In Leucocyte Typing IV. White Cell Differentiation Antigens - International workshop and conference. Knapp W, Doeken B, Gilks EP, Schmidt RE, Stein H, von dem Borne A.E.G.Kr. Eds. Vienna, Oxford University Press.1989.
  • Protein number
    UniProt: P22083 (Human)
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    The CD15/ Lewis X antigen/ alpha-(1 antibody3)-fucosyltransferase 4 is a α- or alpha protein sometimes glycoprotein present in blood. Antigens are peptides or recombinant or native dependent on the production method.
  • Gene target
  • Gene symbol
    FUT4
  • Short name
    CD15/ Lewis X antigen/ alpha-(1 antibody3)-fucosyltransferase 4
  • Technique
    antigen, antigenes
  • Isotype
    IgM
  • Label
    unlabeled
  • Alternative name
    CD15/ Lewis X protein/ a-(1 antibody3)-fucosyltransferase 4
  • Alternative technique
    antigenes
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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