CD114 / G-CSFR monoclonal antibody

• Catalog number
  1P-157-T100
• Price
  Please ask
• Size
  100 assays

• Long name
  Mouse Monoclonal Antibody against Human CD114 / G-CSFR, Clone: LMM741
• Antigen
  CD114 / G-CSFR
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  Mouse
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  LMM741
• Applications
  FC
• Immunogen
  CHO cells transfected with human CD114
• Format conjugation
  PE
• Specificity
  The mouse monoclonal antibody LMM741 recognizes CD114 (colony stimulating factor 3 receptor), a 130 kDa transmembrane glycoprotein expressed on granulocytes and their differentiation stages, on monocytes, platelets, endothelial cells and placenta. It is absent from lymphocytes and erythrocytes._x000D_ _x000D_ HLDA VI; WS Code MA98
• Research area
  CD and Related Antigens (Human)
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD114 / G-CSFR, Clone: LMM741 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD114 / G-CSFR (granulocyte colony-stimulating factor receptor, also known as CSF3R) is a type I transmembrane glycoprotein which upon binding of its ligand (G-CSF, granulocyte colony-stimulating factor) homodimerizes and activates signaling transduction to mediate cell proliferation, survival, and differentiation. It is expressed by granulocytes at all stages of their differentiation, as well as by monocytes, dendritic cells, and mature platelets. Among non-hematopoietic cells, it is expressed e.g. by endothelial cells, placenta, trophoblasts, and many tumor cell lines. This antigen is a target for stem cell mobilization for blood stem cell transplantation, for enhancing recovery of myelopoiesis following chemotherapy and in the treatment of patients with severe chronic neutropenia.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  *Cimato TR, Palka BA, Lang JK, Young RF: LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axis. PLoS One. 2013 Aug 26;8(8):e73861., *Tchou J, Zhang PJ, Bi Y, Satija C, Marjumdar R, Stephen TL, Lo A, Chen H, Mies C, June CH, Conejo-Garcia J, Puré E: Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer. Hum Pathol. 2013 Nov;44(11):2549-57., *Gibbs KD Jr, Gilbert PM, Sachs K, Zhao F, Blau HM, Weissman IL, Nolan GP, Majeti R: Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood. 2011 Apr 21;117(16):4226-33. doi: 10.1182/blood-2010-07-298232., *Layton JE, Hall NE, Connell F, Venhorst J, Treutlein HR: Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor. J Biol Chem. 2001 Sep 28;276(39):36779-87., *Layton JE, Shimamoto G, Osslund T, Hammacher A, Smith DK, Treutlein HR, Boone T: Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor. Evidence that Glu19 of G-CSF interacts with Arg288 of the receptor. J Biol Chem. 1999 Jun 18;274(25):17445-51., *Layton JE, Iaria J, Smith DK, Treutlein HR: Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis. J Biol Chem. 1997 Nov 21;272(47):29735-41.
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD114   G-CSFR   monoclonal  
• Gene symbol
  CSF3R, IGHV3-71, HLA-G, NCAPG, FOLR3, SNRPG, GNAO1, CSF1R, SFTA2, BCL2L14
• Short name
  Anti-CD114 / G-CSFR Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD114 / G-CSFR
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2439
• Gene
  CSF3R
• Long gene name
  colony stimulating factor 3 receptor
• Synonyms gene
  • CD114
• Synonyms gene name
  • colony stimulating factor 3 receptor (granulocyte)
• Synonyms
  • GCSFR
• GenBank acession
  • M59820
• Locus
  1p34.3
• Discovery year
  1990-12-10
• Entrez gene record
  1441
• Pubmed identfication
  • 1371413
• RefSeq identity
  • NM_156039
• Classification
  • Fibronectin type III domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000008010
• Locus Specific Databases
  • LRG_144

Gene info

• Identity
  HGNC:5621
• Gene
  IGHV3-71
• Long gene name
  immunoglobulin heavy variable 3-71 (pseudogene)
• Synonyms gene
  • IGHV3-G
• Synonyms gene name
  • immunoglobulin heavy variable 3-71
  • immunoglobulin heavy variable 3-G pseudogene (provisional)
  • immunoglobulin heavy variable 3-G (provisional)
  • immunoglobulin heavy variable 3-71 pseudogene
• Synonyms
  • IGHV3-g
• GenBank acession
  • AB019437
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28411
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151881

Gene info

• Identity
  HGNC:4964
• Gene
  HLA-G
• Long gene name
  major histocompatibility complex, class I, G
• Synonyms gene name
  • HLA-G histocompatibility antigen, class I, G
• Synonyms name
  • b2 microglobulin
• Locus
  6p22.1
• Discovery year
  1990-09-10
• Entrez gene record
  3135
• RefSeq identity
  • NM_002127
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031157
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:24304
• Gene
  NCAPG
• Long gene name
  non-SMC condensin I complex subunit G
• Synonyms gene name
  • non-SMC condensin I complex, subunit G
• Synonyms
  • FLJ12450
  • hCAP-G
  • CAP-G
  • YCG1
• Synonyms name
  • chromosome condensation protein G
• GenBank acession
  • AF331796
• Locus
  4p15.31
• Discovery year
  2006-09-04
• Entrez gene record
  64151
• Pubmed identfication
  • 10910072
  • 11136719
• RefSeq identity
  • NM_022346
• Classification
  • Armadillo like helical domain containing
  • Condensin I subunits
• VEGA ID
  OTTHUMG00000128539

Gene info

• Identity
  HGNC:3795
• Gene
  FOLR3
• Long gene name
  folate receptor gamma
• Synonyms gene name
  • folate receptor 3 (gamma)
  • folate receptor 3
• Synonyms
  • FR-G
  • FRγ
• GenBank acession
  • U08471
• Locus
  11q13.4
• Discovery year
  1997-09-05
• Entrez gene record
  2352
• Pubmed identfication
  • 8110752
• RefSeq identity
  • NM_000804
• VEGA ID
  OTTHUMG00000167870

Gene info

• Identity
  HGNC:11163
• Gene
  SNRPG
• Long gene name
  small nuclear ribonucleoprotein polypeptide G
• Synonyms
  • Sm-G
• GenBank acession
  • X85373
• Locus
  2p13.3
• Discovery year
  1990-06-13
• Entrez gene record
  6637
• Pubmed identfication
  • 7744013
• Classification
  • Sm spliceosomal proteins
• VEGA ID
  OTTHUMG00000129670

Gene info

• Identity
  HGNC:4389
• Gene
  GNAO1
• Long gene name
  G protein subunit alpha o1
• Synonyms gene name
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
• Synonyms
  • G-ALPHA-o
• Locus
  16q13
• Discovery year
  1988-04-24
• Entrez gene record
  2775
• Pubmed identfication
  • 1899283
  • 11395521
• RefSeq identity
  • NM_020988
• Classification
  • G protein subunits alpha, group i
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133241

Gene info

• Identity
  HGNC:2433
• Gene
  CSF1R
• Long gene name
  colony stimulating factor 1 receptor
• Synonyms gene
  • FMS
• Synonyms gene name
  • McDonough feline sarcoma viral (v-fms) oncogene homolog
• Synonyms
  • C-FMS
  • CSFR
  • CD115
• GenBank acession
  • U63963
• Locus
  5q32
• Discovery year
  2001-06-22
• Entrez gene record
  1436
• Pubmed identfication
  • 1611909
• RefSeq identity
  • NM_005211
• Classification
  • Immunoglobulin like domain containing
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000130050

Gene info

• Identity
  HGNC:18386
• Gene
  SFTA2
• Long gene name
  surfactant associated 2
• Synonyms gene
  • SFTPG
• Synonyms gene name
  • surfactant associated protein G
• Synonyms
  • SP-G
• GenBank acession
  • AY102070
• Locus
  6p21.33
• Discovery year
  2002-05-01
• Entrez gene record
  389376
• Pubmed identfication
  • 22768197
  • 23094088
• RefSeq identity
  • NM_205854
• VEGA ID
  OTTHUMG00000031183

Gene info

• Identity
  HGNC:16657
• Gene
  BCL2L14
• Long gene name
  BCL2 like 14
• Synonyms gene name
  • BCL2-like 14 (apoptosis facilitator)
• Synonyms
  • BCLG
  • BCL-G
• GenBank acession
  • AF281254
• Locus
  12p13.2
• Discovery year
  2004-02-09
• Entrez gene record
  79370
• Pubmed identfication
  • 11054413
• RefSeq identity
  • NM_030766
• Classification
  • BCL2 family
• VEGA ID
  OTTHUMG00000159528

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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