CD111 / Nectin-1 monoclonal antibody

• Catalog number
  11-780-C100
• Price
  Please ask
• Size
  100ug

• Long name
  Mouse Monoclonal Antibody against Human CD111 / Nectin-1, Clone: R1.302
• Antigen
  CD111
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  R1.302
• Applications
  FC, IP, WB, IHC, ICC
• Immunogen
  NIH/3T3 cells transfected with human CD111
• Format conjugation
  purified; unconjugated
• Specificity
  The mouse monoclonal antibody R1.302 recognizes CD111 (also known as Nectin 1), a 75 kDa type I transmembrane glycoprotein broadly expressed on endothelial cells, epithelial cells, neuronal cells, megakaryocytes, and CD34-positive stem cells.
• Research area
  CD and Related Antigens (Human)
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD111 / Nectin-1, Clone: R1.302 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD111, also known as nectin-1, is a calcium-independent cell-cell adhesion transmembrane glycoprotein involved in organization of adherens junctions and tight junctions in epithelial and endothelial cells. It also serves as a target molecule for entry of herpes simplex virus (HSV-1, HSV-2) and pseudorabies virus (PRV) into epithelial and neuronal cells. CD111 is connected with actin cytoskeleton through afadin. Mutations in the gene for CD111 cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  Contact us for the most recent list of references
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD111   Nectin-1   monoclonal  
• Gene symbol
  NECTIN1
• Short name
  Anti-CD111 / Nectin-1 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD111 / Nectin-1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9706
• Gene
  NECTIN1
• Long gene name
  nectin cell adhesion molecule 1
• Synonyms gene
  • HVEC
  • ED4
  • PVRL1
• Synonyms gene name
  • poliovirus receptor-related 1 (herpesvirus entry mediator C)
• Synonyms
  • PRR
  • PRR1
  • PVRR1
  • SK-12
  • HIgR
  • CLPED1
  • CD111
  • OFC7
• Synonyms name
  • nectin
• GenBank acession
  • X76400
• Locus
  11q23.3
• Discovery year
  1999-11-15
• Entrez gene record
  5818
• Pubmed identfication
  • 7721102
  • 9616127
• Classification
  • C2-set domain containing
  • V-set domain containing
  • Nectins and nectin-like molecules
  • CD molecules
• VEGA ID
  OTTHUMG00000166177

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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