Cathepsin B (CTSB) Inhibitor Screening Kit (Fluorometric)

  • Catalog number
    K147-100
  • Price
    Please ask
  • Size
    100 assays
  • Description
    Only kit on the market to screen Cathepsin B inhibitors
  • Summary
    • Detection method- Fluorescence (Ex/Em = 400/505 nm) • Applications- Screen/study/characterize potential inhibitors of Cathepsin B.
  • Detection Method
    Fluorescence (Ex/Em = 400/505 nm)
  • Applications
    Screen/study/characterize potential inhibitors of Cathepsin B.
  • Features Benefits
    • Simple & convenient • High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin B • Cathepsin B inhibitor, F-F-FMK is included in the kit
  • Storage Conditions
    -20°C
  • Shipping Conditions
    gel pack
  • Shelf life
    12 months
  • Background
    Cathepsin B (CTSB, EC 3.4.22.1) is a lysosomal cysteine proteinase that is suggested to participate in intracellular degradation and turnover of proteins. It has also been implicated in tumor invasion and metastasis. Biovision’s Cathepsin B Inhibitor Screening Kit utilizes the ability of Cathepsin B to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin B-specific inhibitor, the cleavage of the substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize the potential inhibitors of Cathepsin B.
  • Gene
    CTS protease activity also measured by zymograph electrophoresis of Cathepsins. This cathepsin is supplied in 1.
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    CTSB
  • Short name
    Cathepsin B (CTSB) Inhibitor Screening Kit (Fluorometric)
  • Alternative name
    Cathepsin B (cathepsin B) suppressor detection reagent (fluorescence)
  • Alternative technique
    kits
  • Alternative to gene target
    cathepsin B, APPS and CPSB, CTSB and IDBG-7654 and ENSG00000164733 and 1508, proteoglycan binding, nuclei, Ctsb and IDBG-172314 and ENSMUSG00000021939 and 13030, CTSB and IDBG-629395 and ENSBTAG00000012442 and 281105
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