Caspase 9 Antibody
2x Caspase 9 Antibody found in Bioss Primary Unconjugated Antibodies
- CategoryPrimary Antibodies
- Modification site(s)Unmodified antibody
- ClonalityPolyclonal antibody
- Clone numberPolyclonal antibody
- Concentration1ug per 1ul
- Gene ID number842
- Swiss ProtP55211
- Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
- Background of the target antigenInvolved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
- Purification methodThis antibody was purified via Protein A.
- Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
- Synonym namesMCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP9
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies
bs-0049R | Caspase 9 Antibodysize: 0.1ml | 322.31 USD
bs-0050R | Caspase-9 Antibodysize: 0.1ml | 322.31 USD
- Catalog numberbs-0050R
- Price322.31 USD
- Long nameCaspase-9 Primary Polyclonal Antibody
- Also known asCaspase-9 PAb
- Target AntigenCaspase-9
- SpecificityThis is a highly specific antibody against Caspase-9.
- Immunogen range280-330/416
- Subcellular locationIntracellular
- SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Caspase-9 subunit p35
- Tested ApplicationsWB, IHC-P, IF(IHC-P)
- Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
- Cross reactivityHuman
- PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
- DescriptionHuman and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
- French translationanticorps
- Gene target
- Short nameCaspase-9 Antibody
- Alternative namecaspase-9 (Antibody to)
1. Gene info
- Long gene namecaspase 9
- Synonyms gene name
- caspase 9, apoptosis-related cysteine protease
- caspase 9, apoptosis-related cysteine peptidase
- Synonyms name
- GenBank acession
- Discovery year1996-11-11
- Entrez gene record
- Pubmed identfication
- RefSeq identity
- Caspase recruitment domain containing
- Protein phosphatase 1 regulatory subunits
- Havana BLAST/BLAT
- ConceptScope note:Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
- Tree numbers
- PubMedNeuronal cell death is induced via cleavage of caspase-4 in endoplasmic reticulum cells under stress in vitro.results suggest that caspase-4 directly activates caspase-9 by the processing of procaspase-9 at Asp-315 in endoplasmic reticulum stress-induced neuronal apoptosisCaspase-4 expression is essential for efficient nucleotide-binding domain leucine-rich repeat containing, Pyrin domain containing-3 and for absent in melanoma 2 inflammasome-dependent proIL-1beta activation in macrophagesTLR3 stimulation in keratinocytes induces a caspase-4 dependent release of pro-IL-1beta, but further processing to active IL-1beta is limited. Furthermore, TLR3 stimulation results in pyroptotic- and apoptotic cell death.function of caspase-4/5/11 represents a new mode of pattern recognition in immunity and also an unprecedented means of caspase activationimplicate caspase-4 as a critical regulator of noncanonical inflammasome activation that initiates defense against bacterial pathogens in primary macrophagescaspase-4 activation alone is sufficient to induce pyroptosis, this process depends on the NLRP3 inflammasome activation to drive IL-1beta maturation.
- Gene ontology - Biological process
- Gene ontology - Cellular component
- Gene ontology - Molecular function
- Entrez Gene