Caspase 14 Antibody

• Catalog number
  bs-10136R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Caspase 14 Primary Polyclonal Antibody
• Also known as
  Caspase 14 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Caspase 14
• Specificity
  This is a highly specific antibody against Caspase 14.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  200-242/242
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Caspase 14
• Gene ID number
  23581
• Swiss Prot
  P31944
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Caspase-14; CASP-14; CASP14
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• French translation
  anticorps

• Gene target
  Caspase  
• Gene symbol
  CASP14, CARD14
• Short name
  Anti-Caspase 14
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Caspase 14 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1502
• Gene
  CASP14
• Long gene name
  caspase 14
• Synonyms gene name
  • caspase 14, apoptosis-related cysteine protease
  • caspase 14, apoptosis-related cysteine peptidase
• Synonyms
  • MICE
  • MGC119078
  • MGC119079
• Synonyms name
  • apoptosis-related cysteine protease
• Locus
  19p13.12
• Discovery year
  1998-11-09
• Entrez gene record
  23581
• Pubmed identfication
  • 10203698
  • 9792675
  • 15301553
• RefSeq identity
  • NM_012114
• Classification
  • Caspases
• VEGA ID
  OTTHUMG00000183205

Gene info

• Identity
  HGNC:16446
• Gene
  CARD14
• Long gene name
  caspase recruitment domain family member 14
• Synonyms gene
  • PSORS2
• Synonyms gene name
  • psoriasis susceptibility 2
  • caspase recruitment domain family, member 14
• Synonyms
  • CARMA2
  • BIMP2
• GenBank acession
  • AF322642
• Locus
  17q25.3
• Discovery year
  2002-09-19
• Entrez gene record
  79092
• Pubmed identfication
  • 11278692
  • 11356195
  • 22521418
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000177549
• Locus Specific Databases
  • LRG_1330

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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