Caspase 14 Antibody
-
Catalog numberbs-10136R
-
PricePlease ask
-
Size0.1ml
-
-
Long nameCaspase 14 Primary Polyclonal Antibody
-
Also known asCaspase 14 PAb
-
CategoryPrimary Antibodies
-
ConjugationUnconjugated
-
Target AntigenCaspase 14
-
SpecificityThis is a highly specific antibody against Caspase 14.
-
Modification sNone
-
Modification site sUnmodified antibody
-
ClonalityPolyclonal antibody
-
Clone numberPolyclonal antibody
-
Concentration1ug per 1ul
-
Immunogen range200-242/242
-
Subcellular locationCytoplasm, Nucleus
-
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Caspase 14
-
Gene ID number23581
-
Swiss ProtP31944
-
Tested ApplicationsWB, IHC-P, IF(IHC-P)
-
Recommended dilutionsWB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
-
Cross reactivityHuman, Mouse, Rat
-
Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Background of the target antigenNon-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
-
Synonym namesCaspase-14; CASP-14; CASP14
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
DescriptionHuman and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
-
French translationanticorps
-
Gene target
-
Gene symbolCASP14, CARD14
-
Short nameAnti-Caspase 14
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
HostRabbit (Oryctolagus cuniculus)
-
IsotypeImmunoglobulin G (IgG)
-
Alternative nameCaspase 14 Polyclonal Antibody
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namecaspase 14
-
Synonyms gene name
- caspase 14, apoptosis-related cysteine protease
- caspase 14, apoptosis-related cysteine peptidase
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year1998-11-09
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Caspases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namecaspase recruitment domain family member 14
-
Synonyms gene
-
Synonyms gene name
- psoriasis susceptibility 2
- caspase recruitment domain family, member 14
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2002-09-19
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Membrane associated guanylate kinases
- PDZ domain containing
- Caspase recruitment domain containing
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data