Calreticulin, human recombinant

• Catalog number
  7570-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60
• Alternative_names
  CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60
• Description
  Involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Molecular Weight
  ~55.0 kDa. Human calreticulin (aa 18-417) is fused at the C-terminus to a His-tag.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  6 months
• Appearance
  Liquid
• Physical form description
  0.2 um-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
• Background Information
  Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Calreticulin  
• Gene symbol
  CALR4P, CALR, CALR3
• Short name
  Calreticulin, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Calreticulin, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:35456
• Gene
  CALR4P
• Long gene name
  calreticulin 4, pseudogene
• Locus
  1p32.3
• Discovery year
  2010-03-12
• Entrez gene record
  441884
• Pubmed identfication
  • 20210993
• VEGA ID
  OTTHUMG00000008233

Gene info

• Identity
  HGNC:1455
• Gene
  CALR
• Long gene name
  calreticulin
• Synonyms
  • RO
  • SSA
  • cC1qR
  • CRT
  • FLJ26680
• Synonyms name
  • Sicca syndrome antigen A (autoantigen Ro; calreticulin)
  • autoantigen Ro
• GenBank acession
  • M84739
• Locus
  19p13.13
• Discovery year
  1990-09-10
• Entrez gene record
  811
• Pubmed identfication
  • 2365822
• RefSeq identity
  • NM_004343
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000180574
• Locus Specific Databases
  • LRG_828

Gene info

• Identity
  HGNC:20407
• Gene
  CALR3
• Long gene name
  calreticulin 3
• Synonyms
  • CRT2
  • FLJ25355
  • MGC26577
  • CT93
• Synonyms name
  • cancer/testis antigen 93
  • calsperin
• GenBank acession
  • AK058084
• Locus
  19p13.11
• Discovery year
  2003-02-04
• Entrez gene record
  125972
• Pubmed identfication
  • 12384296
• RefSeq identity
  • NM_145046
• VEGA ID
  OTTHUMG00000152571
• Locus Specific Databases
  • LRG_422

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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