Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human C1orf112
Swiss Prot Q9NSG2
Specificity This is a highly specific antibody against C1orf112.
Immunogen range 250-300/853
Subcellular location Cytoplasm, Nucleus
Tested applications IF(IHC-P)
Clone Polyclonal antibody
Modification Site None
Synonyms Uncharacterized protein C1orf112; C1orf112
Purification Purified by Protein A.
Crossreactivity Human, Mouse, Rat
Gene ID Number 55732
Recommended dilutions IF(IHC-P)(1:50-200)
Background of the antigen Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf112 gene product has been provisionally designated C1orf112 pending further characterization.
Concentration 1ug per 1ul
Target Antigen C1orf112
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.