NGF(β-NGF)

• Catalog number
  E21-060
• Price
  Please ask
• Size
  10ug

• Shipping_Temperature
  Ambient
• Product_State
  Lyophilized
• Formulation_Description
  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.0.
• Storage
  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Background
  Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse protein and shows cross-species reactivity.
• Alternative Names
  Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
• Expression system
  E.coli

• Gene target
  NGF   β-NGF  
• Gene symbol
  NGF, NGF-AS1
• Short name
  NGF(β-NGF)
• Species
  Human
• Alternative name
  nerve growth factor (beta polypeptide)(β-nerve growth factor (beta polypeptide))
• Alternative to gene target
  nerve growth factor (beta polypeptide), Beta-NGF and HSAN5 and NGFB, NGF and IDBG-101347 and ENSG00000134259 and 4803, growth factor activity, Extracellular, Ngf and IDBG-180362 and ENSMUSG00000027859 and 18049, NGF and IDBG-648895 and ENSBTAG00000007446 and 281350

Gene info

• Identity
  HGNC:7808
• Gene
  NGF
• Long gene name
  nerve growth factor
• Synonyms gene
  • NGFB
• Synonyms gene name
  • nerve growth factor (beta polypeptide)
• Locus
  1p13.2
• Discovery year
  2001-06-22
• Entrez gene record
  4803
• RefSeq identity
  • NM_002506
• Classification
  • Neurotrophins
• VEGA ID
  OTTHUMG00000011880
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • LRG_260

Gene info

• Identity
  HGNC:53922
• Gene
  NGF-AS1
• Long gene name
  NGF antisense RNA 1
• Synonyms
  • RP4-663N10.1
• Locus
  1p13.2
• Discovery year
  2018-06-08
• Pubmed identfication
  • 29855537
• Classification
  • Antisense RNAs

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