BRD3-Bromodomain1 (29-145 aa) (His-Tagged) human recombinant

  • Catalog number
    7256-1000
  • Price
    Please ask
  • Size
    1 mg
  • Synonyms
    KIAA0043, RING3L
  • Alternative_names
    KIAA0043, RING3L
  • Description
    A protein involved in chromatin targeting
  • Recombinant
    Yes
  • Source
    E. coli
  • Purity by SDS PAGE
    ≥98%
  • Assay
    SDS-PAGE
  • Molecular Weight
    16.2 kDa
  • Storage Temp
    -80°C
  • Shipping
    Dry Ice
  • Shelf Life
    12 months
  • Concentration
    2 mg/ml
  • Appearance
    Liquid
  • Physical form description
    rh-BRD3-BD1 is supplied as a solution in PBS Buffer containing 10% glycerol
  • Background Information
    The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. The recombinant protein includes Bromodomain-containing protein 3 (contains 29-145 aa) with N-terminal His-tag.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Conjugation
    histidine
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    BRD3, SNORD114-29, SNORD115-29, SNORD116-29, IGLV3-29, IGHV3-29, MIR145, IGKV2-29, IGKV2D-29, ERVK-29
  • Short name
    BRD3-Bromodomain1 (29-145 aa) (His-Tagged) recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Label
    his-tagged
  • Species
    Human, Humans
  • Alternative name
    BRD3-Bromodomain1 (29-145 aa) (histidine-Tagged) H. sapiens Rec.
  • Alternative technique
    rec
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin lambda variable 3-29 (pseudogene)
  • Synonyms gene name
    • immunoglobulin lambda variable 3-29
  • GenBank acession
  • Locus
  • Discovery year
    2000-05-08
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin lambda locus at 22q11.2
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable 3-29 (pseudogene)
  • Synonyms gene name
    • immunoglobulin heavy variable 3-29
    • immunoglobulin heavy variable 3-29 pseudogene
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-04
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin kappa variable 2-29
  • Synonyms gene name
    • immunoglobulin kappa variable 2-29 (gene/pseudogene)
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-18
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin kappa locus at 2p11.2
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    endogenous retrovirus group K member 29
  • Synonyms gene name
    • endogenous retrovirus group K, member 29
  • GenBank acession
  • Locus
  • Discovery year
    2014-01-03
  • Pubmed identfication
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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