BRCA1 (Ser1387) Antibody, ALEXA FLUOR 647

Catalog number

bs-12885R-A647
Price

Please ask
Size

100ul

Long name

BRCA1 (Ser1387) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
Also known as

Anti-BRCA1 Ser1387 PAb ALEXA FLUOR 647
Category

Conjugated Primary Antibodies
Conjugated with

ALEXA FLUOR® 647
Host Organism

Rabbit (Oryctolagus cuniculus)
Target Antigen

BRCA1 Ser1387
Specificity

This is a highly specific antibody against BRCA1 Ser1387.
Modification

Phosphorylation
Modification Site

Ser1387
Clonality

Polyclonal
Clone

Polyclonal antibody
Concentration

1ug per 1ul
Source

KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1387
Gene ID Number

672
Tested applications

IF(IHC-P)
Recommended dilutions

IF(IHC-P)(1:50-200)
Crossreactivity

Human
Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
Purification

Purified by Protein A.
Storage conditions

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Excitation emission

650nm/665nm
Synonyms

BRCA1 phospho S1387; BRCA1 phospho Ser1387; p-BRCA1 S1387; p-BRCA1 Ser1387; p-BRCA1 phospho S1387; BRCA 1; BRCA1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1.
Properties

For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-BRCA1 Ser1387 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation

Alexa Fluor, ALEXA FLUOR 647
French translation

anticorps

Gene target

BRCA1 Ser1387
Gene symbol

BRCA1, BRCA1P1
Short name

Anti-BRCA1 Ser1387
Technique

Antibody, antibodies against human proteins, antibodies for
Isotype

Immunoglobulin G (IgG)
Label

ALEXA FLUOR 647
Alternative name

BRCA1 (Ser1387) Polyclonal Antibody, ALEXA FLUOR 647
Alternative technique

antibodies
Alternative to gene target

breast cancer 1, early onset, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, BRCA1 and IDBG-52172 and ENSG00000012048 and 672, androgen receptor binding, nuclei, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120

Gene info

Identity

HGNC:1100
Gene

BRCA1
Long gene name

BRCA1 DNA repair associated
Synonyms gene name
- breast cancer 1, early onset
- breast cancer 1
Synonyms
- RNF53
- BRCC1
- PPP1R53
- FANCS
Synonyms name
GenBank acession
- U14680
Locus

17q21.31
Discovery year

1991-02-20
Entrez gene record

672
Pubmed identfication
- 1676470
- 25472942
RefSeq identity
- NM_007294
Classification
- Ring finger proteins
- Protein phosphatase 1 regulatory subunits
- BRCA1 A complex
- BRCA1 B complex
- BRCA1 C complex
- FA complementation groups
VEGA ID

OTTHUMG00000157426
Locus Specific Databases

Gene info

Identity

HGNC:28470
Gene

BRCA1P1
Long gene name

BRCA1 pseudogene 1
Synonyms
Synonyms name
- like-BRCA1
Locus

17q21.31
Discovery year

2005-05-26
Entrez gene record

394269
Pubmed identfication
RefSeq identity
- NG_003183

MeSH Data

Name

Blotting, Western
Concept

Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

BRCA1 (Ser1387) Antibody, ALEXA FLUOR 647

Gene info

Gene info

MeSH Data

Product images

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