Borrelidin

Alternative_name

Treponemycin; U 78548; C2989
Description

A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC₅₀ = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Also acts as a CDK inhibitor.
CAS Number

7184-60-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₈H₄₃NO₆
Molecular Weight

489.64
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~10 mg/ml)
Handling

Protect from light and moisture
Tag Line

An angiogenesis inhibitor
Storage Condition

-20 ̊C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD01740784
PubChem CID

6436801
PubChem CID Link
SMILES

CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
InChi

InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25-,27+/m0/s1
InChi Key

OJCKRNPLOZHAOU-UGKRXNSESA-N
Data Sheet Link
MSDS Available

Yes