Cubilin Antibody
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Catalog numberbs-3901R
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PricePlease ask
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Size0.1ml
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Long nameCubilin Primary Polyclonal Antibody
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Also known asCubilin PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenCubilin
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SpecificityThis is a highly specific antibody against Cubilin.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range50-90/3623
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Subcellular locationIntracellular
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cubilin
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Gene ID number8029
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Swiss ProtO60494
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Tested ApplicationsIHC-P, IF(IHC-P)
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Recommended dilutionsIHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenCotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesIFCR; MGA1; gp280; Cubilin; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor; CUBN
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCUBNP3, CUBN, CUBNP1
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Short nameAnti-Cubilin
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameCubilin Polyclonal Antibody
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namecubilin pseudogene 3
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Synonyms gene name
- cubilin (intrinsic factor-cobalamin receptor) pseudogene 3
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Locus
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Discovery year2013-01-03
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecubilin
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Synonyms gene
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Synonyms gene name
- cubilin (intrinsic factor-cobalamin receptor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-11-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namecubilin pseudogene 1
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Synonyms gene name
- cubilin (intrinsic factor-cobalamin receptor) pseudogene 1
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Locus
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Discovery year2013-01-03
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Entrez gene record
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data