BMP8B, human recombinant
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Catalog number7304-100
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PricePlease ask
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Size100 ug
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SynonymsBMP8, OP2, Bone morphogenetic protein 8B
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Alternative_namesBMP8, OP2, Bone morphogenetic protein 8B
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DescriptionSignaling molecule that can induce ectopic bone growth
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥90%
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AssaySDS-PAGE
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Endotoxin Level< 1.0 EU per 1 microgram of protein
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Molecular Weight18.1 kDa (162 aa, 264-402 aa + His tag), confirmed by MALDI-TOF.
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Storage Temp-80°C
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ShippingDry Ice
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Shelf Life12 months
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Concentration1 mg/ml
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AppearanceLiquid
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Physical form description1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol
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Background InformationThe bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E.coli.
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Amino acid sequenceMGSSHHHHHH SSGLVPRGSH MGSAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolBMP8B-AS1, BMP8B
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Short nameBMP8B, recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative namebone morphogenetic protein 8b, H. sapiens Rec.
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Alternative techniquerec
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Alternative to gene targetbone morphogenetic protein 8b, BMP8 and OP2, BMP8B and IDBG-96764 and ENSG00000116985 and 353500,656, growth factor activity, Extracellular
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Gene info
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Identity
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Gene
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Long gene nameBMP8B antisense RNA 1
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Locus
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Discovery year2019-05-17
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Entrez gene record
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene namebone morphogenetic protein 8b
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Synonyms gene
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Synonyms gene name
- bone morphogenetic protein 8 (osteogenic protein 2)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-11-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Bone morphogenetic proteins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data