BLNK(Tyr96) Antibody, Cy7 Conjugated

• Catalog number
  bs-3054R-Cy7
• Price
  Please ask
• Size
  0.1ml

• Long name
  BLNK(Tyr96) Polyclonal Antibody, Cy7 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy7
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  BLNK Tyr96
• Specificity
  This is a highly specific antibody against BLNK Tyr96.
• Modification
  Phosphorylation
• Modification site
  Tyr96
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  70-120/456
• Subcellular location
  Cytoplasm, Cell membrane
• Source
  KLH conjugated synthetic phosphopeptide derived from human BLNK around the phosphorylation site of Tyr96 [DS(p-Y)EP]
• Gene ID number
  29760
• Swiss Prot
  Q8WV28
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  743nm/767nm
• Synonyms
  bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; BLNK
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugated
  These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
• Additional conjugation
  Cy7
• French translation
  anticorps

• Gene target
  BLNK   Tyr96   Conjugated  
• Gene symbol
  BLNK
• Short name
  Anti-BLNK Tyr96
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy7
• Alternative name
  Anti-BLNK Tyr96 PAb Cy7
• Alternative technique
  antibodies
• Alternative to gene target
  B-cell linker, BLNK and IDBG-83724 and ENSG00000095585 and 29760, protein binding, Plasma membranes, Blnk and IDBG-165316 and ENSMUSG00000061132 and 17060, BT.24520 and IDBG-638042 and ENSBTAG00000021358 and 510393

Gene info

• Identity
  HGNC:14211
• Gene
  BLNK
• Long gene name
  B cell linker
• Synonyms
  • SLP65
  • Ly57
  • SLP-65
  • BLNK-s
  • BASH
  • bca
• Synonyms name
  • B-cell adapter containing a SH2 domain protein
  • B-cell activation
  • Src homology [SH2] domain-containing leukocyte protein of 65 kD
  • B cell adaptor containing SH2 domain
• GenBank acession
  • AF068180
• Locus
  10q24.1
• Discovery year
  2001-07-16
• Entrez gene record
  29760
• Pubmed identfication
  • 9697839
  • 10583958
• RefSeq identity
  • NM_013314
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000018827
• Locus Specific Databases
  • BLNKbase: Mutation registry for BLNK deficiency
  • LRG_21

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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