Biotinylated PD-1/PDCD1, Human Recombinant
-
Catalog numberP1038-50
-
PricePlease ask
-
Size50 ug
-
-
SynonymsPDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l
-
Alternative_namesPDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l
-
DescriptionInhibits the T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.
-
RecombinantYes
-
SourceE. coli
-
Purity by SDS PAGE> 90%
-
AssaySDS-PAGE
-
Purity> 90%
-
Activity Specifications test methodMeasured by its binding ability in functional ELISA
-
Biological activityMeasured by its binding ability to bind Human PD-L1 in a functional ELISA with a linear range of 0.125-1 µg/ml.
-
ResultsMeasured by its binding ability to bind Human PD-L1 in a functional ELISA with a linear range of 0.125-1 µg/ml.
-
Molecular Weight19.7 kDa
-
Storage Temp-20°C
-
ShippingGel Pack
-
Shelf Life12 months
-
AppearanceLiquid
-
Physical form description0.5 mg/ml solution in in PBS containing 20% glycerol
-
Background InformationProgrammed death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen, as a protein standard, or in cell biology research applications.
-
HandlingCentrifuge the vial prior to opening.
-
UsageFor Research Use Only! Not to be used in humans
-
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional sourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolPDCD1, SNCA, ENPP2, SPATA2, ENPP3, PDCD1LG2, CD274, IGHVII-1-1, MIR1-1, TRUND-NNN8-1
-
Short nameBiotinylated PD-1/PDCD1, Recombinant
-
TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
SpeciesHuman, Humans
-
Alternative nameBiotinylated PD-1/programmed cellular death 1, H. sapiens Rec.
-
Alternative techniquerec
-
Alternative to gene targetprogrammed cell death 1, CD279 and hPD-1 and hPD-l and hSLE1 and PD-1 and PD1 and SLEB2, PDCD1 and IDBG-85346 and ENSG00000188389 and 5133, protein binding, Cell surfaces, Pdcd1 and IDBG-184148 and ENSMUSG00000026285 and 18566, PDCD1 and IDBG-642702 and ENSBTAG00000011543 and 613842
-
Gene info
-
Identity
-
Gene
-
Long gene nameprogrammed cell death 1
-
Synonyms gene
-
Synonyms gene name
- systemic lupus erythematosus susceptibility 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1994-05-24
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- V-set domain containing
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namesynuclein alpha
-
Synonyms gene
-
Synonyms gene name
- Parkinson disease (autosomal dominant, Lewy body) 4
- synuclein, alpha (non A4 component of amyloid precursor)
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1995-01-24
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 2
-
Synonyms gene
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1995-08-10
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namespermatogenesis associated 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2001-03-15
-
Entrez gene record
-
RefSeq identity
-
Classification
- Protein phosphatase 1 regulatory subunits
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 3
-
Synonyms gene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1995-08-10
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameprogrammed cell death 1 ligand 2
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2003-11-14
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- B7 family
- CD molecules
- Immunoglobulin like domain containing
- Receptor ligands
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameCD274 molecule
-
Synonyms gene
-
Synonyms gene name
- programmed cell death 1 ligand 1
- CD274 antigen
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2003-11-13
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Receptor ligands
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin heavy variable (II)-1-1 (pseudogene)
-
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-04-17
-
Entrez gene record
-
RefSeq identity
-
Classification
- Immunoglobulin heavy locus at 14q32.33
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 1-1
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR1/206 family
Gene info
-
Identity
-
Gene
-
Long gene nametRNA-undetermined (NNN) 8-1
-
Synonyms gene name
- transfer RNA-undetermined (NNN) 8-1
-
GenBank acession
-
Locus
-
Discovery year2014-06-20
-
Entrez gene record
-
Pubmed identfication
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data