Beta-site APP-cleaving enzyme 1 isoform C (BACE) polyclonal antibody

Product category

Orbigen
You will recive this

Ice Packs
Product Family

Qualified Antibodies
Name of the reagent

Genetic Disease Markers
More allele products
Properties

If you buy Antibodies supplied by allele they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Description

Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
Group

Polyclonals and antibodies
About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation

anticorps

Gene target

Beta-site APP-cleaving isoform BACE
Gene symbol

APP-DT, APP, PABPC4, NAE1, BACE1
Short name

Beta-site APP-cleaving enzyme 1 isoform C (BACE) polyclonal antibody
Technique

Polyclonal, Antibody, Enzyme, antibodies against human proteins, antibodies for, enzymes, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
Alternative name

b-site amyloid beta (A4) precursor protein-cleaving enzyme 1 isoform C (BACE) polyclonal (antibody to-)
Alternative technique

polyclonals, antibodies, enzymes
Alternative to gene target

amyloid beta (A4) precursor protein, AAA and ABETA and ABPP and AD1 and APPI and CTFgamma and CVAP and PN-II and PN2, APP and IDBG-1100 and ENSG00000142192 and 351, growth factor receptor binding, nuclei, App and IDBG-172954 and ENSMUSG00000022892 and 11820, APP and IDBG-630293 and ENSBTAG00000017753 and 280722

Identity

HGNC:620
Gene

APP
Long gene name

amyloid beta precursor protein
Synonyms gene
- AD1
Synonyms gene name
- Alzheimer disease
- amyloid beta (A4) precursor protein
Synonyms
- alpha-sAPP
Synonyms name
- peptidase nexin-II
GenBank acession
- M15533
Locus

21q21.3
Discovery year

1986-01-01
Entrez gene record

351
Pubmed identfication
- 1679289
RefSeq identity
- NM_000484
Classification
- Receptor ligands
VEGA ID

OTTHUMG00000078438
Locus Specific Databases
- Alzheimer Disease & Frontotemporal Dementia Mutation Database

Identity

HGNC:8557
Gene

PABPC4
Long gene name

poly(A) binding protein cytoplasmic 4
Synonyms gene name
- poly(A)-binding protein, cytoplasmic 4 (inducible form)
- poly(A) binding protein, cytoplasmic 4 (inducible form)
Synonyms
- iPABP
- APP-1
Synonyms name
- activated-platelet protein 1
- Inducible poly(A)-binding protein
GenBank acession
- U33818
Locus

1p34.3
Discovery year

1999-12-17
Entrez gene record

8761
Pubmed identfication
- 10543404
RefSeq identity
- NM_001135653
Classification
- RNA binding motif containing
- Small nucleolar RNA protein coding host genes
VEGA ID

OTTHUMG00000009097

Identity

HGNC:933
Gene

BACE1
Long gene name

beta-secretase 1
Synonyms gene
- BACE
Synonyms gene name
- beta-site APP-cleaving enzyme
- beta-site APP-cleaving enzyme 1
GenBank acession
- AF190725
Locus

11q23.3
Discovery year

1999-10-29
Entrez gene record

23621
Pubmed identfication
- 10531052
Classification
- Peptidase family A1
VEGA ID

OTTHUMG00000160636

Name

Blotting, Western
Concept

Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data