beta-Amyloid 1-42 Antibody, ALEXA FLUOR 350
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Catalog numberbs-0076R-A350
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PricePlease ask
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Size100ul
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Long namebeta-Amyloid 1-42 Antibody, ALEXA FLUOR 350 Conjugated
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Also known asAnti-beta-Amyloid 1-42 PAb ALEXA FLUOR 350
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 350
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target Antigenbeta-Amyloid 1-42
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SpecificityThis is a highly specific antibody against beta-Amyloid 1-42.
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ModificationUnmodified
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Modification SiteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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Subcellular locationExtracellular, Helical
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human beta-Amyloid(35-42)
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Gene ID Number351
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Swiss ProtP05067
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenFunctions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses.
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission343nm/442nm
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SynonymsAAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; Amyloid beta A4 protein; APP; Alzheimer disease amyloid protein; Amyloid precursor protein; Beta-amyloid precursor protein; Cerebral vascular amyloid peptide; PreA4; Protease nexin-II; A4
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PropertiesFor facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR 350
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French translationanticorps
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Gene target
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Gene symbolSNORD115-42, IGLVI-42, IGKV1D-42, IGHV3-42, RNU6-42P, DSCAM, NFX1, KIR2DL1, IGHVII-1-1, MIR1-1
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Short nameAnti-beta-Amyloid 1-42
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 350
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Alternative namebeta-Amyloid 1-42 Antibody, ALEXA FLUOR 350
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 115-42
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin lambda variable (I)-42 (pseudogene)
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Synonyms gene name
- immunoglobulin lambda variable (I)-42
- immunoglobulin lambda variable (I)-42 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-05-08
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin lambda locus at 22q11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 1D-42 (non-functional)
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Synonyms gene name
- immunoglobulin kappa variable 1D-42
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin kappa locus at 2p11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 3-42 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable 3-42
- immunoglobulin heavy variable 3-42 pseudogene
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNA, U6 small nuclear 42, pseudogene
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Synonyms gene
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Synonyms gene name
- RNA, U6 small nuclear 42
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Locus
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Discovery year2008-06-10
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Entrez gene record
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameDS cell adhesion molecule
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Synonyms gene name
- Down syndrome cell adhesion molecule
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-06-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ig-like cell adhesion molecule family
- I-set domain containing
- Fibronectin type III domain containing
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namenuclear transcription factor, X-box binding 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-05-26
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Pubmed identfication
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Classification
- PHD finger proteins
- Ring finger proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namekiller cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1
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Synonyms gene name
- killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-11-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Killer cell immunoglobulin like receptors
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable (II)-1-1 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1-1
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1/206 family
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
