BCR-RET Mutant, Active

Products_type

Recombinant Protein
Products_short_name

[BCR-RET]
Other_names

[Homo sapiens breakpoint cluster region, mRNA; Breakpoint cluster region protein; breakpoint cluster region protein; BCR, RhoGEF and GTPase activating protein; Renal carcinoma antigen NY-REN-26]
Products_gene_name

[BCR-RET]
Products_gene_name_syn

[BCR: ALL; CML; PHL; BCR1; D22S11; D22S662; FLJ16453]
Other_gene_names

[BCR; BCR; ALL; CML; PHL; BCR1; D22S11; D22S662; BCR1; D22S11]
Form

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Storage_stability

Store product at -70 degree C.For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Tested_application

Kinase Assay

Gene target

BCR-RET Mutant Active
Gene symbol

BCRP1, BCRP2, BCRP4, BCR, GOLGA5, RET
Short name

BCR-RET Mutant, Active
Host

Sf9 insect cells using baculovirus
Alternative name

BCR-ret proto-oncogene Mutant, functionnal
Alternative to gene target

ret proto-oncogene, CDHF12 and CDHR16 and HSCR1 and MEN2A and MEN2B and MTC1 and PTC and RET-ELE1 and RET51, RET and IDBG-71064 and ENSG00000165731 and 5979, transferase activity, Plasma membranes, Ret and IDBG-181393 and ENSMUSG00000030110 and 19713, RET and IDBG-628722 and ENSBTAG00000000570 and 515924

Identity

HGNC:1015
Gene

BCRP2
Long gene name

BCR pseudogene 2
Synonyms gene
- BCR2
- BCRL2
Synonyms gene name
- breakpoint cluster region-like 2
- breakpoint cluster region pseudogene 2
Synonyms
- BCR-2
Locus

22q11.21
Discovery year

2001-06-22
Entrez gene record

400892
Pubmed identfication
- 3267213
RefSeq identity
- NG_007131
VEGA ID

OTTHUMG00000150627

Identity

HGNC:1017
Gene

BCRP4
Long gene name

BCR pseudogene 4
Synonyms gene
- BCR4
- BCRL4
Synonyms gene name
- breakpoint cluster region-like 4
- breakpoint cluster region pseudogene 4
Synonyms
- BCR-4
GenBank acession
- D87002
Locus

22q11.22
Discovery year

2001-06-22
Entrez gene record

616
Pubmed identfication
- 9074928
RefSeq identity
- NG_000002
VEGA ID

OTTHUMG00000151175

Identity

HGNC:1014
Gene

BCR
Long gene name

BCR activator of RhoGEF and GTPase
Synonyms gene
- D22S11
- BCR1
Synonyms gene name
- breakpoint cluster region
- BCR, RhoGEF and GTPase activating protein
Synonyms
- D22S662
- CML
- PHL
- ALL
Locus

22q11.23
Discovery year

1986-01-01
Entrez gene record

613
Pubmed identfication
- 1657398
- 18070886
RefSeq identity
- NM_004327
Classification
- C2 domain containing
- My-T-BRC complex
- Dbl family Rho GEFs
- Pleckstrin homology domain containing
VEGA ID

OTTHUMG00000150655
Locus Specific Databases
- LRG_1112

Identity

HGNC:9967
Gene

RET
Long gene name

ret proto-oncogene
Synonyms gene
- HSCR1
- MEN2A
- MTC1
- MEN2B
Synonyms gene name
- multiple endocrine neoplasia and medullary thyroid carcinoma 1
- Hirschsprung disease 1
Synonyms
- PTC
- CDHF12
- RET51
- CDHR16
Synonyms name
GenBank acession
- BC004257
Locus

10q11.21
Discovery year

1990-07-15
Entrez gene record

5979
Pubmed identfication
- 2687772
- 1611909
RefSeq identity
- NM_020975
Classification
- Cadherin related
- Receptor tyrosine kinases
VEGA ID

OTTHUMG00000018024
Locus Specific Databases
- LRG_518