Bcl10 Antibody

• Catalog number
  R30577
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Bcl10
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting points. Titration of the Bcl10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Bcl10 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  O95999
• Purity
  Antigen affinity
• Description
  BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue(MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain(CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are though to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are though to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
• Immunogen
  An amino acid sequence from the N-terminus of human Bcl10 (ERHFDHLRAKKILSRED) was used as the immunogen for this Bcl10 antibody (100% homologous in human, mouse and rat).
• Storage
  After reconstitution, the Bcl10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Bcl10  
• Gene symbol
  BCL10-AS1, BCL10, CARD11
• Short name
  Anti-Bcl10
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Bcl10
• Alternative technique
  antibodies
• Alternative to gene target
  B-cell CLL/lymphoma 10, c-E10 and CARMEN and CIPER and CLAP and mE10, BCL10 and IDBG-100044 and ENSG00000142867 and 8915, NF-kappaB binding, nuclei, Bcl10 and IDBG-198751 and ENSMUSG00000028191 and 12042, BCL10 and IDBG-637289 and ENSBTAG00000013851 and 540824

Gene info

• Identity
  HGNC:55868
• Gene
  BCL10-AS1
• Long gene name
  BCL10 antisense RNA 1
• Locus
  1p22.3
• Discovery year
  2021-09-06
• Entrez gene record
  646626
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:989
• Gene
  BCL10
• Long gene name
  BCL10 immune signaling adaptor
• Synonyms gene name
  • B cell CLL/lymphoma 10
  • BCL10, immune signaling adaptor
• Synonyms
  • CARMEN
  • CIPER
  • mE10
  • c-E10
  • CLAP
• Synonyms name
  • CARD-like apoptotic protein
  • CARD-containing apoptotic signaling protein
  • CARD containing molecule enhancing NF-kB
  • caspase-recruiting domain-containing protein
  • CARD-containing proapoptotic protein
• GenBank acession
  • AJ006288
• Locus
  1p22.3
• Discovery year
  1999-01-08
• Entrez gene record
  8915
• Pubmed identfication
  • 9989495
• RefSeq identity
  • NM_003921
• Classification
  • CBM complex
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000009965
• Locus Specific Databases
  • LRG_1210

Gene info

• Identity
  HGNC:16393
• Gene
  CARD11
• Long gene name
  caspase recruitment domain family member 11
• Synonyms gene name
  • caspase recruitment domain family, member 11
• Synonyms
  • CARMA1
  • BIMP3
• Synonyms name
  • card-maguk protein 1
  • bcl10-interacting maguk protein 3
• GenBank acession
  • AF322641
• Locus
  7p22.2
• Discovery year
  2001-08-13
• Entrez gene record
  84433
• Pubmed identfication
  • 11278692
  • 11356195
• RefSeq identity
  • NM_032415
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
  • Caspase recruitment domain containing
  • CBM complex
• VEGA ID
  OTTHUMG00000023023
• Locus Specific Databases
  • LRG_729

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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