PD-L1/B7-H1/CD274(Fc fusion)

• Catalog number
  E21-M79
• Price
  Please ask
• Size
  10ug

• Shipping_Temperature
  Ambient
• Product_State
  Lyophilized
• Formulation_Description
  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
• Storage
  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Background
  CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
• Alternative Names
  Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1; Programmed Death Ligand 1; B7 Homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
• Expression system
  Human cells
• Description
  Fusion proteins or chimeric proteins are proteins created through the joining of two or more genes that originally coded for separate proteins. A GFP gene is often used as tag to a reporter gene. Fusion lentiverctors can be used as viral particles to produce proteins that carry for example a GFP tag. Antigen purification of recombinant fusion tag proteins is a frequent strategy using a Fralg tag.

• Gene target
  PD-L1/B7-H1/CD274  
• Gene symbol
  CD274, PDCD1LG2, VSIR, H1-9P, HHLA2, RLN1, H1-8, RNY4P2, LRRC23, ENPP2
• Short name
  PD-L1/B7-H1/CD274(Fc )
• Technique
  FC
• Species
  Human
• Alternative name
  PD-L1/B7-H1/CD274 molecule(fragment c fusion)
• Alternative to gene target
  CD274 molecule, CD274 and IDBG-47487 and ENSG00000120217 and 29126, protein binding, Cell surfaces, Cd274 and IDBG-157249 and ENSMUSG00000016496 and 60533, PD-L1 and IDBG-631351 and ENSBTAG00000000095 and 533834

Gene info

• Identity
  HGNC:17635
• Gene
  CD274
• Long gene name
  CD274 molecule
• Synonyms gene
  • PDCD1LG1
• Synonyms gene name
  • programmed cell death 1 ligand 1
  • CD274 antigen
• Synonyms
  • B7-H
  • B7H1
  • PD-L1
  • PDL1
  • B7-H1
• Synonyms name
  • B7 homolog 1
• GenBank acession
  • AF177937
• Locus
  9p24.1
• Discovery year
  2003-11-13
• Entrez gene record
  29126
• Pubmed identfication
  • 11015443
  • 10581077
• RefSeq identity
  • NM_014143
• Classification
  • Receptor ligands
  • C2-set domain containing
  • V-set domain containing
  • B7 family
  • CD molecules
• VEGA ID
  OTTHUMG00000019503

Gene info

• Identity
  HGNC:18731
• Gene
  PDCD1LG2
• Long gene name
  programmed cell death 1 ligand 2
• Synonyms
  • PD-L2
  • Btdc
  • PDL2
  • bA574F11.2
  • CD273
  • B7-DC
• Synonyms name
  • B7 dendritic cell molecule
• GenBank acession
  • AF344424
• Locus
  9p24.1
• Discovery year
  2003-11-14
• Entrez gene record
  80380
• Pubmed identfication
  • 11224527
• RefSeq identity
  • NM_025239
• Classification
  • B7 family
  • CD molecules
  • Immunoglobulin like domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000019504

Gene info

• Identity
  HGNC:30085
• Gene
  VSIR
• Long gene name
  V-set immunoregulatory receptor
• Synonyms gene
  • C10orf54
• Synonyms gene name
  • chromosome 10 open reading frame 54
• Synonyms
  • SISP1
  • GI24
  • B7-H5
  • B7H5
  • VISTA
  • PD-1H
  • Dies1
• Synonyms name
  • stress induced secreted protein 1
  • V-domain Ig suppressor of T cell activation
  • PDCD1 homolog
• GenBank acession
  • AF193048
• Locus
  10q22.1
• Discovery year
  2005-10-06
• Entrez gene record
  64115
• Pubmed identfication
  • 12975309
  • 24691993
  • 25279955
• RefSeq identity
  • NM_022153
• Classification
  • B7 family
  • V-set domain containing
• VEGA ID
  OTTHUMG00000018426

Gene info

• Identity
  HGNC:30616
• Gene
  H1-9P
• Long gene name
  H1.9 linker histone, pseudogene
• Synonyms gene
  • HILS1
  • H1-9
• Synonyms gene name
  • histone linker H1 domain, spermatid-specific 1
  • histone linker H1 domain, spermatid-specific 1 (pseudogene)
  • H1.9 linker histone (pseudogene)
• Synonyms
  • H1.9
• GenBank acession
  • AY286318
• Locus
  17q21.33
• Discovery year
  2005-12-16
• Entrez gene record
  373861
• Pubmed identfication
  • 12920187
  • 30068355
• RefSeq identity
  • NR_024193
• Classification
  • H1 histones
• VEGA ID
  OTTHUMG00000162025

Gene info

• Identity
  HGNC:4905
• Gene
  HHLA2
• Long gene name
  HERV-H LTR-associating 2
• Synonyms
  • B7H7
  • B7-H5
  • B7y
  • B7-H7
• GenBank acession
  • AF126162
• Locus
  3q13.13
• Discovery year
  1999-09-07
• Entrez gene record
  11148
• Pubmed identfication
  • 10444326
  • 23784006
  • 22488247
• RefSeq identity
  • NM_007072
• Classification
  • C1-set domain containing
  • V-set domain containing
  • B7 family
• VEGA ID
  OTTHUMG00000159224

Gene info

• Identity
  HGNC:10026
• Gene
  RLN1
• Long gene name
  relaxin 1
• Synonyms gene name
  • relaxin 1 (H1)
• Synonyms
  • H1
• Synonyms name
  • prorelaxin H1
• Locus
  9p24.1
• Discovery year
  2001-06-22
• Entrez gene record
  6013
• Classification
  • Neuropeptides
• VEGA ID
  OTTHUMG00000019495

Gene info

• Identity
  HGNC:18463
• Gene
  H1-8
• Long gene name
  H1.8 linker histone
• Synonyms gene
  • H1FOO
• Synonyms gene name
  • H1 histone family, member O, oocyte-specific
  • H1 histone family member O oocyte specific
• GenBank acession
  • AY158091
• Locus
  3q22.1
• Discovery year
  2003-05-23
• Entrez gene record
  132243
• Pubmed identfication
  • 12408966
• RefSeq identity
  • NM_153833
• Classification
  • H1 histones
• VEGA ID
  OTTHUMG00000159541

Gene info

• Identity
  HGNC:10246
• Gene
  RNY4P2
• Long gene name
  RNY4 pseudogene 2
• Synonyms gene name
  • RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
  • RNA, Ro-associated Y4 pseudogene 2
• Synonyms
  • hY4.B7
• GenBank acession
  • M77130
• Locus
  17q21.31
• Discovery year
  1993-08-25
• Entrez gene record
  6088
• RefSeq identity
  • NG_005037

Gene info

• Identity
  HGNC:19138
• Gene
  LRRC23
• Long gene name
  leucine rich repeat containing 23
• Synonyms
  • B7
  • LRPB7
• GenBank acession
  • BC014450
• Locus
  12p13.31
• Discovery year
  2006-01-24
• Entrez gene record
  10233
• Pubmed identfication
  • 11830501
  • 11826754
• RefSeq identity
  • NM_006992
• VEGA ID
  OTTHUMG00000156668

Gene info

• Identity
  HGNC:3357
• Gene
  ENPP2
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 2
• Synonyms gene
  • PDNP2
• Synonyms
  • ATX
  • PD-IALPHA
• Synonyms name
  • autotaxin
• GenBank acession
  • D45421
• Locus
  8q24.12
• Discovery year
  1995-08-10
• Entrez gene record
  5168
• Pubmed identfication
  • 8586446
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000164995

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